Brian C DeFelice
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Explore the profile of Brian C DeFelice including associated specialties, affiliations and a list of published articles.
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27
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Recent Articles
11.
Sarkar A, Jin Y, DeFelice B, Logan C, Yang Y, Anbarchian T, et al.
Elife
. 2023 Jan;
12.
PMID: 36719070
Nutrient availability fluctuates in most natural populations, forcing organisms to undergo periods of fasting and re-feeding. It is unknown how dietary changes influence liver homeostasis. Here, we show that a...
12.
Spring J, Beilinson V, DeFelice B, Sanchez J, Fischbach M, Chervonsky A, et al.
bioRxiv
. 2023 Jan;
PMID: 36711645
Both viruses and bacteria produce 'pathogen associated molecular patterns' that may affect microbial pathogenesis and anti-microbial responses. Additionally, bacteria produce metabolites while viruses could change metabolic profiles of the infected...
13.
DeFelice B, Fiehn O, Belafsky P, Ditterich C, Moore M, Abouyared M, et al.
Diagnostics (Basel)
. 2022 Apr;
12(4).
PMID: 35453845
: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and...
14.
Vigers T, Vanderlinden L, Johnson R, Carry P, Yang I, DeFelice B, et al.
Metabolites
. 2021 Aug;
11(8).
PMID: 34436483
Environmental factors including viruses, diet, and the metabolome have been linked with the appearance of islet autoimmunity (IA) that precedes development of type 1 diabetes (T1D). We measured global DNA...
15.
Han S, Van Treuren W, Fischer C, Merrill B, DeFelice B, Sanchez J, et al.
Nature
. 2021 Jul;
595(7867):415-420.
PMID: 34262212
Gut microorganisms modulate host phenotypes and are associated with numerous health effects in humans, ranging from host responses to cancer immunotherapy to metabolic disease and obesity. However, difficulty in accurate...
16.
Buckner T, Vanderlinden L, DeFelice B, Carry P, Kechris K, Dong F, et al.
Diabetologia
. 2021 Apr;
64(8):1785-1794.
PMID: 33893822
Aims/hypothesis: Oxylipins are lipid mediators derived from polyunsaturated fatty acids. Some oxylipins are proinflammatory (e.g. those derived from arachidonic acid [ARA]), others are pro-resolving of inflammation (e.g. those derived from...
17.
Buckner T, Vanderlinden L, Johnson R, DeFelice B, Carry P, Seifert J, et al.
Pediatr Res
. 2020 Jul;
89(6):1530-1540.
PMID: 32726799
Background: Oxylipins are formed from oxidation of omega-6 (n6) and omega-3 (n3) fatty acids (FAs). Evidence for inflammatory effects comes mostly from adults. Methods: Oxylipins from n6 FA (27 n6-oxylipins)...
18.
Johnson R, Vanderlinden L, DeFelice B, Uusitalo U, Seifert J, Fan S, et al.
Pediatr Diabetes
. 2020 Jul;
21(7):1202-1209.
PMID: 32686271
Objective: Our aim was to elucidate the role of diet in type 1 diabetes (T1D) by examining combinations of nutrient intake in the progression from islet autoimmunity (IA) to T1D....
19.
DeFelice B, Pedersen T, Shorrosh H, Johnson R, Seifert J, Norris J, et al.
J Steroid Biochem Mol Biol
. 2019 Nov;
197:105519.
PMID: 31715316
There is need for a single assay able to quantify the most biologically active metabolite, 1α,25-dihydroxy-vitamin-D3, and the recently discovered biologically distinct C3-epimers of 25OHD, in addition to traditional vitamin...
20.
Johnson R, Vanderlinden L, DeFelice B, Kechris K, Uusitalo U, Fiehn O, et al.
Sci Rep
. 2019 Oct;
9(1):14819.
PMID: 31616039
The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352...