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Brian A Dougherty

Explore the profile of Brian A Dougherty including associated specialties, affiliations and a list of published articles. Areas
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Citations 607
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Recent Articles
11.
Constantine K, Krystek S, Healy M, Doyle M, Siemers N, Thanassi J, et al.
Protein Sci . 2005 Jun; 14(6):1472-84. PMID: 15929997
CFE88 is a conserved essential gene product from Streptococcus pneumoniae. This 227-residue protein has minimal sequence similarity to proteins of known 3D structure. Sequence alignment models and computational protein threading...
12.
Steele C, Chen Y, Dougherty B, Li W, Hofstead S, Lam K, et al.
Arch Biochem Biophys . 2005 May; 438(1):1-10. PMID: 15878763
The conversion of alpha-phenylalanine to beta-phenylalanine is the first committed step in the biosynthesis of the C-13 side chain of Taxol. Thus, the novel enzyme responsible for this step, phenylalanine...
13.
Carver T, Bordeau B, Cummings M, Petrella E, Pucci M, Zawadzke L, et al.
J Biol Chem . 2005 Jan; 280(12):11704-12. PMID: 15634672
The protein product of an essential gene of unknown function from Streptococcus pneumoniae was expressed and purified for screening in the ThermoFluor affinity screening assay. This assay can detect ligand...
14.
Thanassi J, Dougherty T, Dougherty B, Pucci M
Nucleic Acids Res . 2002 Jul; 30(14):3152-62. PMID: 12136097
The recent availability of bacterial genome sequence information permits the identification of conserved genes that are potential targets for novel antibiotic drug discovery. Using a coupled bioinformatic/experimental approach, a list...
15.
Lewis 3rd F, Dougherty B
Methods Mol Biol . 2002 Jan; 182:173-87. PMID: 11768964
No abstract available.
16.
Dougherty B, Smith H
Microbiology (Reading) . 1999 Mar; 145 ( Pt 2):401-409. PMID: 10075422
Genes required for natural transformation of Haemophilus influenzae Rd were identified by a cassette mutagenesis protocol consisting of the following steps: random insertional mutagenesis, phenotypic screening, sequencing of genome sequence...