Brett M Hirsch
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Explore the profile of Brett M Hirsch including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
113
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Recent Articles
1.
Feng M, Namanja-Magliano H, Rajagopalan S, Mishra T, Ducati R, Hirsch B, et al.
ACS Infect Dis
. 2023 Mar;
9(4):966-978.
PMID: 36920074
is found in the gut lining of more than half of the world's population, causes gastric ulcers, and contributes to stomach cancers. Menaquinone synthesis in relies on the rare futalosine...
2.
Wong M, Meas M, Adams C, Hernandez S, Green V, Montoya M, et al.
Microbiol Spectr
. 2022 May;
10(3):e0247121.
PMID: 35612315
Serological surveillance studies of infectious diseases provide population-level estimates of infection and antibody prevalence, generating crucial insight into population-level immunity, risk factors leading to infection, and effectiveness of public health...
3.
Harijan R, Hoff O, Ducati R, Firestone R, Hirsch B, Evans G, et al.
J Med Chem
. 2019 Mar;
62(7):3286-3296.
PMID: 30860833
Bacterial 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase (MTAN) hydrolyzes adenine from its substrates to form S-methyl-5-thioribose and S-ribosyl-l-homocysteine. MTANs are involved in quorum sensing, menaquinone synthesis, and 5'-methylthioadenosine recycling to S-adenosylmethionine. Helicobacter pylori...
4.
Harris L, Harijan R, Ducati R, Evans G, Hirsch B, Schramm V
ACS Chem Biol
. 2017 Nov;
13(1):152-160.
PMID: 29178779
Phosphoribosyl transferases (PRTs) are essential in nucleotide synthesis and salvage, amino acid, and vitamin synthesis. Transition state analysis of several PRTs has demonstrated ribocation-like transition states with a partial positive...
5.
Hirsch B, Burgos E, Schramm V
ACS Chem Biol
. 2014 Jul;
9(10):2255-62.
PMID: 25051211
Macrodomains, including the human macrodomain 1 (MacroD1), are erasers of the post-translational modification of monoadenosinediphospho-ribosylation and hydrolytically deacetylate the sirtuin product O-acetyl-ADP-ribose (OAADPr). OAADPr has been reported to play a...
6.
Hao Y, Wang C, Cao B, Hirsch B, Song J, Markowitz S, et al.
Cancer Cell
. 2013 May;
23(5):583-93.
PMID: 23643389
PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase α, is frequently mutated in human cancers. Most of these mutations occur at two hot-spots: E545K and H1047R located in...
7.
Hirsch B, Hao Y, Li X, Wesdemiotis C, Wang Z, Zheng W
Bioorg Med Chem Lett
. 2011 Jul;
21(16):4753-7.
PMID: 21752644
In the current study, we have identified N(ε)-thiocarbamoyl-lysine (TuAcK) as a general sirtuin inhibitory warhead which was shown to be able to confer potent sirtuin inhibition. This inhibition was also...
8.
Hirsch B, Zheng W
Mol Biosyst
. 2010 Sep;
7(1):16-28.
PMID: 20842312
Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein deacetylases that can catalyze the β-nicotinamide adenine dinucleotide (β-NAD(+))-dependent deacetylation of N(ε)-acetyl-lysine on protein substrates, with...
9.
Jamonnak N, Hirsch B, Pang Y, Zheng W
Bioorg Chem
. 2009 Nov;
38(1):17-25.
PMID: 19914676
Peptides containing L-N(epsilon)-acetyl-lysine (L-AcK) or its side chain modified analogs were prepared and assayed using SIRT1, the prototypical human silent information regulator 2 (Sir2) enzyme. While previous studies showed that...