Brett L Roberts
Overview
Explore the profile of Brett L Roberts including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
6
Citations
84
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Xie H, Li C, Tang H, Tandon I, Liao J, Roberts B, et al.
J Med Chem
. 2023 Feb;
66(4):2904-2917.
PMID: 36749666
Glutarimides such as thalidomide, pomalidomide, and lenalidomide are the most frequently used ligands to recruit E3 ubiquitin ligase cereblon (CRBN) for the development of proteolysis-targeting chimeras (PROTACs). Due to the...
2.
Yang K, Zhou Y, Roberts B, Nie X, Tang W
STAR Protoc
. 2021 Feb;
2(1):100288.
PMID: 33532735
The discovery of potent cell-permeable E3 ubiquitin ligase ligands can significantly facilitate the development of proteolysis targeting chimeras (PROTACs). Here, we present a protocol to determine the binding affinity of...
3.
Roberts B, Ma Z, Gao A, Leisten E, Yin D, Xu W, et al.
ACS Chem Biol
. 2020 Apr;
15(6):1487-1496.
PMID: 32255606
Proteolysis targeting chimeras (PROTACs) have emerged as useful chemical probes and potential therapeutics by taking advantage of the ubiquitin-proteasome system to degrade intracellular disease-associated proteins. PROTACs are heterobifunctional molecules composed...
4.
Glazier D, Liao J, Roberts B, Li X, Yang K, Stevens C, et al.
Bioconjug Chem
. 2020 Apr;
31(5):1213-1233.
PMID: 32227878
RNA plays a myriad of roles in the body including the coding, decoding, regulation, and expression of genes. RNA oligonucleotides have garnered significant interest as therapeutics via antisense oligonucleotides or...
5.
Roberts B, Severance Z, Bensen R, Le-McClain A, Malinky C, Mettenbrink E, et al.
Antiviral Res
. 2019 Jul;
170:104548.
PMID: 31271764
Oxysterol-binding Protein (OSBP) is a human lipid-transport protein required for the cellular replication of many types of viruses, including several human pathogens. The structurally-diverse small molecule compounds OSW-1, itraconazole (ITZ),...
6.
Roberts B, Severance Z, Bensen R, Le A, Kothapalli N, Nunez J, et al.
ACS Chem Biol
. 2018 Dec;
14(2):276-287.
PMID: 30576108
Oxysterol-binding protein (OSBP) is a lipid transport and regulatory protein required for the replication of Enterovirus genus viruses, which includes many significant human pathogens. Short-term exposure (i.e., 1-6 h) to...