Brett D Keiper
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Explore the profile of Brett D Keiper including associated specialties, affiliations and a list of published articles.
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19
Citations
372
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Recent Articles
1.
Barker B, Cannon C, Umphlett H, Kim E, Keiper B
MicroPubl Biol
. 2025 Mar;
2025.
PMID: 40046037
Cellular identity and fate are determined by the proteins synthesized. Initiation of mRNA translation requires an important translation factor, eIF4G ( in ). Embryos use mRNA translational control for spatial...
2.
Gajjar G, Huggins H, Kim E, Huang W, Bonnet F, Updike D, et al.
bioRxiv
. 2024 Jun;
PMID: 38826235
We studied the function of translation factor eIF4E isoforms in regulating mRNAs in germ cell granules/condensates. Translational control of mRNAs plays an essential role in germ cell gene regulation. Messenger...
3.
Rochester J, Min H, Gajjar G, Sharp C, Maki N, Rollins J, et al.
Dev Biol
. 2022 Oct;
492:200-211.
PMID: 36273621
Germ granules harbor processes that maintain germline integrity and germline stem cell capacity. Depleting core germ granule components in C. elegans leads to the reprogramming of germ cells, causing them...
4.
Huggins H, Keiper B
Front Cell Dev Biol
. 2020 Aug;
8:562.
PMID: 32733883
Translational regulation of mRNAs is critically important for proper gene expression in germ cells, gametes, and embryos. The ability of the nucleus to control gene expression in these systems may...
5.
Huggins H, Subash J, Stoffel H, Henderson M, Hoffman J, Buckner D, et al.
J Cell Sci
. 2020 Feb;
133(6).
PMID: 32079657
Germ cells use both positive and negative mRNA translational control to regulate gene expression that drives their differentiation into gametes. mRNA translational control is mediated by RNA-binding proteins, miRNAs and...
6.
Keiper B
Int J Mol Sci
. 2019 Jan;
20(1).
PMID: 30621249
Cellular mRNAs in plants and animals have a 5'-cap structure that is accepted as the recognition point to initiate translation by ribosomes. Consequently, it was long assumed that the translation...
7.
Yoon D, Cha D, Alfhili M, Keiper B, Lee M
FEBS J
. 2018 May;
285(14):2590-2604.
PMID: 29775245
Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays a critical role at several junctures in animal development. In Caenorhabditis elegans,GLP-1/Notch signaling is...
8.
Flamand M, Wu E, Vashisht A, Jannot G, Keiper B, Simard M, et al.
Nucleic Acids Res
. 2016 Apr;
44(12):5924-35.
PMID: 27095199
Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key roles in mRNA regulation and decay. Reports from mice, zebrafish and Drosophila further...
9.
Morrison J, Friday A, Henderson M, Hao E, Keiper B
Translation (Austin)
. 2016 Jan;
2(1):e28935.
PMID: 26779406
During apoptosis, activated caspases cleave the translation initiation factor eIF4G. This cleavage disrupts cap-dependent mRNA translation initiation within the cell. However, a specific subset of mRNAs can still be recruited...
10.
Friday A, Henderson M, Morrison J, Hoffman J, Keiper B
J Cell Sci
. 2015 Nov;
128(24):4487-98.
PMID: 26542024
Regulated mRNA translation is vital for germ cells to produce new proteins in the spatial and temporal patterns that drive gamete development. Translational control involves the de-repression of stored mRNAs...