Brett Boonen
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Explore the profile of Brett Boonen including associated specialties, affiliations and a list of published articles.
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15
Citations
564
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Recent Articles
1.
Boonen B, Voets T
Cell Calcium
. 2024 Jul;
123:102927.
PMID: 38959762
In order to understand protein function, the field of structural biology makes extensive use of cryogenic electron microscopy (cryo-EM), a technique that enables structure determination at atomic resolution following embedding...
2.
Perniss A, Boonen B, Tonack S, Thiel M, Poharkar K, Alnouri M, et al.
Sci Adv
. 2023 Aug;
9(31):eadg8842.
PMID: 37531421
Host-derived succinate accumulates in the airways during bacterial infection. Here, we show that luminal succinate activates murine tracheal brush (tuft) cells through a signaling cascade involving the succinate receptor 1...
3.
Boonen B, Startek J, Milici A, Lopez-Requena A, Beelen M, Callaerts P, et al.
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681657
Background: The transient receptor potential ankyrin 1 (TRPA1) cation channels function as broadly-tuned sensors of noxious chemicals in many species. Recent studies identified four functional TRPA1 isoforms in (dTRPA1(A) to...
4.
Long W, Fatehi M, Soni S, Panigrahi R, Philippaert K, Yu Y, et al.
J Physiol
. 2020 Jul;
598(19):4321-4338.
PMID: 32721035
Key Points: 25-Hydroxyvitamin D (25OHD) is a partial agonist of TRPV1 whereby 25OHD can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists capsaicin and oleoyl...
5.
Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert A, Timm T, et al.
Immunity
. 2020 Apr;
52(4):683-699.e11.
PMID: 32294408
Mucociliary clearance through coordinated ciliary beating is a major innate defense removing pathogens from the lower airways, but the pathogen sensing and downstream signaling mechanisms remain unclear. We identified virulence-associated...
6.
Talavera K, Startek J, Alvarez-Collazo J, Boonen B, Alpizar Y, Sanchez A, et al.
Physiol Rev
. 2019 Nov;
100(2):725-803.
PMID: 31670612
The transient receptor potential ankyrin (TRPA) channels are Ca-permeable nonselective cation channels remarkably conserved through the animal kingdom. Mammals have only one member, TRPA1, which is widely expressed in sensory...
7.
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
Startek J, Boonen B, Lopez-Requena A, Talavera A, Alpizar Y, Ghosh D, et al.
Elife
. 2019 Jun;
8.
PMID: 31184584
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent evidence that TRPA1 is...
8.
Startek J, Boonen B, Talavera K, Meseguer V
Int J Mol Sci
. 2019 Jan;
20(2).
PMID: 30654572
Transient Receptor Potential ion channels (TRPs) have been described as polymodal sensors, being responsible for transducing a wide variety of stimuli, and being involved in sensory functions such as chemosensation,...
9.
Boonen B, Alpizar Y, Meseguer V, Talavera K
Toxins (Basel)
. 2018 Aug;
10(8).
PMID: 30103489
The cellular and systemic effects induced by bacterial lipopolysaccharides (LPS) have been solely attributed to the activation of the Toll-like receptor 4 (TLR4) signalling cascade. However, recent studies have shown...
10.
Boonen B, Alpizar Y, Sanchez A, Lopez-Requena A, Voets T, Talavera K
Cell Calcium
. 2018 Apr;
73:72-81.
PMID: 29689522
Acute neurogenic inflammation and pain associated to bacterial infection have been traditionally ascribed to sensitization and activation of sensory nerve afferents secondary to immune cell stimulation. However, we recently showed...