» Articles » PMID: 30103489

TRP Channels As Sensors of Bacterial Endotoxins

Overview
Journal Toxins (Basel)
Publisher MDPI
Specialty Toxicology
Date 2018 Aug 15
PMID 30103489
Citations 35
Authors
Affiliations
Soon will be listed here.
Abstract

The cellular and systemic effects induced by bacterial lipopolysaccharides (LPS) have been solely attributed to the activation of the Toll-like receptor 4 (TLR4) signalling cascade. However, recent studies have shown that LPS activates several members of the Transient Receptor Potential (TRP) family of cation channels. Indeed, LPS induces activation of the broadly-tuned chemosensor TRPA1 in sensory neurons in a TLR4-independent manner, and genetic ablation of this channel reduced mouse pain and inflammatory responses triggered by LPS and the gustatory-mediated avoidance to LPS in fruit flies. LPS was also shown to activate TRPV4 channels in airway epithelial cells, an effect leading to an immediate production of bactericidal nitric oxide and to an increase in ciliary beat frequency. In this review, we discuss the role of TRP channels as sensors of bacterial endotoxins, and therefore, as crucial players in the timely detection of invading gram-negative bacteria.

Citing Articles

Transient receptor potential channels in dental inflammation and pain perception: A comprehensive review.

Chantadul V, Rotpenpian N, Arayapisit T, Wanasuntronwong A Heliyon. 2025; 11(2):e41730.

PMID: 39872449 PMC: 11761930. DOI: 10.1016/j.heliyon.2025.e41730.


Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study.

Pan H, Liu C, Zhu H, Zhang G J Headache Pain. 2024; 25(1):196.

PMID: 39528917 PMC: 11555962. DOI: 10.1186/s10194-024-01906-z.


Human Salivary Microbiota Diversity According to Ethnicity, Sex, TRPV1 Variants and Sensitivity to Capsaicin.

Vinerbi E, Morini G, Picozzi C, Tofanelli S Int J Mol Sci. 2024; 25(21).

PMID: 39519137 PMC: 11546822. DOI: 10.3390/ijms252111585.


TRPA1 Influences Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation.

Yadav M, Chaudhary P, Ratley G, DSouza B, Kaur M, Ganesan S Int J Mol Sci. 2024; 25(18).

PMID: 39337422 PMC: 11432213. DOI: 10.3390/ijms25189933.


The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.

Nawarathna G, Fakhruddin K, Shorbagi A, Samaranayake L Gut Microbiome (Camb). 2024; 4:e10.

PMID: 39295900 PMC: 11406377. DOI: 10.1017/gmb.2023.7.


References
1.
Montell C, Birnbaumer L, Flockerzi V . The TRP channels, a remarkably functional family. Cell. 2002; 108(5):595-8. DOI: 10.1016/s0092-8674(02)00670-0. View

2.
Pocock T, Foster R, Bates D . Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol. 2003; 286(3):H1015-26. DOI: 10.1152/ajpheart.00826.2003. View

3.
Vincent F, Acevedo A, Nguyen M, Dourado M, DeFalco J, Gustafson A . Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009; 389(3):490-4. DOI: 10.1016/j.bbrc.2009.09.007. View

4.
Launay P, Fleig A, Perraud A, Scharenberg A, Penner R, Kinet J . TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002; 109(3):397-407. DOI: 10.1016/s0092-8674(02)00719-5. View

5.
Secco D, Paron J, de Oliveira S, Ferreira S, Silva J, Cunha F . Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide. 2004; 9(3):153-64. DOI: 10.1016/j.niox.2003.11.001. View