TRP Channels As Sensors of Bacterial Endotoxins

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2018 Aug 15

PMID 30103489

Citations 35

Authors

Brett Boonen

Yeranddy A Alpizar

Victor M Meseguer

Karel Talavera

Affiliations

Soon will be listed here.

Abstract

The cellular and systemic effects induced by bacterial lipopolysaccharides (LPS) have been solely attributed to the activation of the Toll-like receptor 4 (TLR4) signalling cascade. However, recent studies have shown that LPS activates several members of the Transient Receptor Potential (TRP) family of cation channels. Indeed, LPS induces activation of the broadly-tuned chemosensor TRPA1 in sensory neurons in a TLR4-independent manner, and genetic ablation of this channel reduced mouse pain and inflammatory responses triggered by LPS and the gustatory-mediated avoidance to LPS in fruit flies. LPS was also shown to activate TRPV4 channels in airway epithelial cells, an effect leading to an immediate production of bactericidal nitric oxide and to an increase in ciliary beat frequency. In this review, we discuss the role of TRP channels as sensors of bacterial endotoxins, and therefore, as crucial players in the timely detection of invading gram-negative bacteria.

Citing Articles

Transient receptor potential channels in dental inflammation and pain perception: A comprehensive review.

Chantadul V, Rotpenpian N, Arayapisit T, Wanasuntronwong A Heliyon. 2025; 11(2):e41730.

PMID: 39872449 PMC: 11761930. DOI: 10.1016/j.heliyon.2025.e41730.

Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study.

Pan H, Liu C, Zhu H, Zhang G J Headache Pain. 2024; 25(1):196.

PMID: 39528917 PMC: 11555962. DOI: 10.1186/s10194-024-01906-z.

Human Salivary Microbiota Diversity According to Ethnicity, Sex, TRPV1 Variants and Sensitivity to Capsaicin.

Vinerbi E, Morini G, Picozzi C, Tofanelli S Int J Mol Sci. 2024; 25(21).

PMID: 39519137 PMC: 11546822. DOI: 10.3390/ijms252111585.

TRPA1 Influences Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation.

Yadav M, Chaudhary P, Ratley G, DSouza B, Kaur M, Ganesan S Int J Mol Sci. 2024; 25(18).

PMID: 39337422 PMC: 11432213. DOI: 10.3390/ijms25189933.

The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.

Nawarathna G, Fakhruddin K, Shorbagi A, Samaranayake L Gut Microbiome (Camb). 2024; 4:e10.

PMID: 39295900 PMC: 11406377. DOI: 10.1017/gmb.2023.7.

References

Montell C, Birnbaumer L, Flockerzi V . The TRP channels, a remarkably functional family. Cell. 2002; 108(5):595-8. DOI: 10.1016/s0092-8674(02)00670-0. View

Pocock T, Foster R, Bates D . Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol. 2003; 286(3):H1015-26. DOI: 10.1152/ajpheart.00826.2003. View

Vincent F, Acevedo A, Nguyen M, Dourado M, DeFalco J, Gustafson A . Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009; 389(3):490-4. DOI: 10.1016/j.bbrc.2009.09.007. View

Launay P, Fleig A, Perraud A, Scharenberg A, Penner R, Kinet J . TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002; 109(3):397-407. DOI: 10.1016/s0092-8674(02)00719-5. View

Secco D, Paron J, de Oliveira S, Ferreira S, Silva J, Cunha F . Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide. 2004; 9(3):153-64. DOI: 10.1016/j.niox.2003.11.001. View

Gees M, Alpizar Y, Boonen B, Sanchez A, Everaerts W, Segal A . Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate. Mol Pharmacol. 2013; 84(3):325-34. DOI: 10.1124/mol.113.085548. View

Alpizar Y, Boonen B, Gees M, Sanchez A, Nilius B, Voets T . Allyl isothiocyanate sensitizes TRPV1 to heat stimulation. Pflugers Arch. 2013; 466(3):507-15. DOI: 10.1007/s00424-013-1334-9. View

Sokabe T, Fukumi-Tominaga T, Yonemura S, Mizuno A, Tominaga M . The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010; 285(24):18749-58. PMC: 2881798. DOI: 10.1074/jbc.M110.103606. View

Moran M, McAlexander M, Biro T, Szallasi A . Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov. 2011; 10(8):601-20. DOI: 10.1038/nrd3456. View

10.

Guler A, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M . Heat-evoked activation of the ion channel, TRPV4. J Neurosci. 2002; 22(15):6408-14. PMC: 6758176. DOI: 20026679. View

11.

dAldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K . Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice. Gastroenterology. 2010; 140(1):275-85. DOI: 10.1053/j.gastro.2010.09.045. View

12.

Hamad A, Clayton A, Islam B, Knox A . Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function. Am J Physiol Lung Cell Mol Physiol. 2003; 285(5):L973-83. DOI: 10.1152/ajplung.00033.2003. View

13.

Soldano A, Alpizar Y, Boonen B, Franco L, Lopez-Requena A, Liu G . Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila. Elife. 2016; 5. PMC: 4907694. DOI: 10.7554/eLife.13133. View

14.

McKemy D, Neuhausser W, Julius D . Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002; 416(6876):52-8. DOI: 10.1038/nature719. View

15.

Kini V, Chavez A, Mehta D . A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. J Biol Chem. 2010; 285(43):33082-33091. PMC: 2963370. DOI: 10.1074/jbc.M110.142034. View

16.

Meyer K, Kaspar B . Making sense of pain: are pluripotent stem cell-derived sensory neurons a new tool for studying pain mechanisms?. Mol Ther. 2014; 22(8):1403-1405. PMC: 4435599. DOI: 10.1038/mt.2014.123. View

17.

Diogenes A, Ferraz C, Akopian A, Henry M, Hargreaves K . LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons. J Dent Res. 2011; 90(6):759-64. DOI: 10.1177/0022034511400225. View

18.

Talavera K, Nilius B, Voets T . Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci. 2008; 31(6):287-95. DOI: 10.1016/j.tins.2008.03.002. View

19.

Mehta D, Ahmmed G, Paria B, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C . RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem. 2003; 278(35):33492-500. DOI: 10.1074/jbc.M302401200. View

20.

Sato Y, Walley K, Klut M, English D, Dyachkova Y, Hogg J . Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression. Am J Respir Crit Care Med. 1999; 159(5 Pt 1):1469-76. DOI: 10.1164/ajrccm.159.5.9808063. View