Brendan D Price
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Explore the profile of Brendan D Price including associated specialties, affiliations and a list of published articles.
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49
Citations
2832
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Recent Articles
1.
Serafim R, Cardoso C, Storti C, da Silva P, Qi H, Parasuram R, et al.
Oncogene
. 2024 Jan;
43(11):804-820.
PMID: 38279062
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the association of HJURP with cancer aggressiveness is not well understood. HJURP...
2.
Qi H, Grace Wright R, Beato M, Price B
Cell Rep
. 2022 Dec;
41(12):111866.
PMID: 36543120
DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free mono(ADP-ribose) (mADPr). Here,...
3.
Sreekumar R, Al-Saihati H, Emaduddin M, Moutasim K, Mellone M, Patel A, et al.
Mol Oncol
. 2021 May;
15(8):2065-2083.
PMID: 33931939
Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of an epithelial to...
4.
House N, Parasuram R, Layer J, Price B
PLoS One
. 2020 Dec;
15(12):e0237759.
PMID: 33332350
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been...
5.
Layer J, Debaize L, Van Scoyk A, House N, Brown A, Liu Y, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27566-27577.
PMID: 33077594
Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the...
6.
Serafim R, Cardoso C, Di Cristofaro L, Soares C, Silva Jr W, Espreafico E, et al.
Cancer Gene Ther
. 2019 May;
27(5):319-329.
PMID: 31138900
The Holliday Junction-Recognition Protein (HJURP) was reported as overexpressed in several cancers and also strongly correlated with poor prognosis of patients, especially in glioblastoma (GBM), the most common and deadly...
7.
Qi H, Price B, Day T
Trends Genet
. 2019 Jan;
35(2):159-172.
PMID: 30595401
Although stress-induced synthesis of mono(ADP-ribose) (mADPr) and poly(ADP-ribose) (pADPr) conjugates by pADPr polymerase (PARP) enzymes has been studied extensively, the removal and degradation of pADPr, as well as the fate...
8.
Zhou J, Li J, Serafim R, Ketchum S, Ferreira C, Liu J, et al.
Nucleic Acids Res
. 2018 Mar;
46(8):3891-3905.
PMID: 29529298
CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that...
9.
Gursoy-Yuzugullu O, Carman C, Price B
Sci Rep
. 2017 Oct;
7(1):12921.
PMID: 29018219
The n-terminal tail of histone H4 recruits repair proteins, including 53BP1, to DNA double-strand breaks (DSB) and undergoes dynamic acetylation during DSB repair. However, how H4 acetylation (H4Ac) recruits repair...
10.
Strobel T, Madlener S, Tuna S, Vose S, Lagerweij T, Wurdinger T, et al.
Sci Rep
. 2017 Aug;
7(1):9674.
PMID: 28852018
Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or aberrant subcellular distribution of Ape1 has been...