Ozge Gursoy-Yuzugullu
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Explore the profile of Ozge Gursoy-Yuzugullu including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
841
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Recent Articles
1.
Gursoy-Yuzugullu O, Carman C, Price B
Sci Rep
. 2017 Oct;
7(1):12921.
PMID: 29018219
The n-terminal tail of histone H4 recruits repair proteins, including 53BP1, to DNA double-strand breaks (DSB) and undergoes dynamic acetylation during DSB repair. However, how H4 acetylation (H4Ac) recruits repair...
2.
Dhar S, Gursoy-Yuzugullu O, Parasuram R, Price B
Philos Trans R Soc Lond B Biol Sci
. 2017 Aug;
372(1731).
PMID: 28847821
The ability of cells to detect and repair DNA double-strand breaks (DSBs) within the complex architecture of the genome requires co-ordination between the DNA repair machinery and chromatin remodelling complexes....
3.
Gursoy-Yuzugullu O, Carman C, Serafim R, Myronakis M, Valente V, Price B
Oncotarget
. 2017 Apr;
8(15):24518-24532.
PMID: 28445939
Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked...
4.
Gursoy-Yuzugullu O, House N, Price B
J Mol Biol
. 2015 Dec;
428(9 Pt B):1846-60.
PMID: 26625977
The ability of cells to detect and repair DNA double-strand breaks (DSBs) is dependent on reorganization of the surrounding chromatin structure by chromatin remodeling complexes. These complexes promote access to...
5.
Gursoy-Yuzugullu O, Ayrapetov M, Price B
Proc Natl Acad Sci U S A
. 2015 Jun;
112(24):7507-12.
PMID: 26034280
The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains. The NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nucleosomes and promoting acetylation of...
6.
Ayrapetov M, Gursoy-Yuzugullu O, Xu C, Xu Y, Price B
Proc Natl Acad Sci U S A
. 2014 Jun;
111(25):9169-74.
PMID: 24927542
Dynamic changes in histone modification are critical for regulating DNA double-strand break (DSB) repair. Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 with histone H3 methylated on...
7.
Yildiz G, Arslan-Ergul A, Bagislar S, Konu O, Yuzugullu H, Gursoy-Yuzugullu O, et al.
PLoS One
. 2013 May;
8(5):e64016.
PMID: 23691139
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development....
8.
Xu Y, Ayrapetov M, Xu C, Gursoy-Yuzugullu O, Hu Y, Price B
Mol Cell
. 2012 Nov;
48(5):723-33.
PMID: 23122415
Chromatin remodeling during DNA double-strand break (DSB) repair is required to facilitate access to and repair of DSBs. This remodeling requires increased acetylation of histones and a shift in nucleosome...
9.
Xu C, Xu Y, Gursoy-Yuzugullu O, Price B
FEBS Lett
. 2012 Oct;
586(21):3920-5.
PMID: 23031826
The repair of DNA double-strand breaks (DSBs) requires remodeling of the local chromatin architecture to allow the repair machinery to access sites of damage. Here, we report that the histone...
10.
Gursoy-Yuzugullu O, Yuzugullu H, Yilmaz M, Ozturk M
Liver Int
. 2011 Mar;
31(4):561-71.
PMID: 21382167
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. Aflatoxins, which may play a causative role in 5-28% of HCCs worldwide, are activated in liver cells and induce...