Brenda Cohen
Overview
Explore the profile of Brenda Cohen including associated specialties, affiliations and a list of published articles.
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9
Citations
414
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Recent Articles
1.
Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al.
Cell Rep
. 2019 Apr;
27(2):599-615.e12.
PMID: 30970261
Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves...
2.
Shen Q, Cohen B, Zheng W, Rahbar R, Martin B, Murakami K, et al.
Cancer Discov
. 2017 Aug;
7(11):1320-1335.
PMID: 28790030
Notch activation, which is associated with basal-like breast cancer (BLBC), normally directs tissue patterning, suggesting that it may shape the tumor microenvironment. Here, we show that Notch in tumor cells...
3.
Francis K, Pang S, Cohen B, Salter H, Homel P
J Wound Ostomy Continence Nurs
. 2017 May;
44(4):374-379.
PMID: 28549048
Purpose: The primary purpose of our study was to determine if there is a difference in the occurrence of hospital-acquired pressure injuries (HAPIs) and incontinence-associated dermatitis (IAD) in incontinent adults...
4.
Dileepan T, Smith E, Knowland D, Hsu M, Platt M, Bittner-Eddy P, et al.
J Clin Invest
. 2015 Dec;
126(1):303-17.
PMID: 26657857
Group A streptococcal (GAS) infection induces the production of Abs that cross-react with host neuronal proteins, and these anti-GAS mimetic Abs are associated with autoimmune diseases of the CNS. However,...
5.
Diaz-Padilla I, Hirte H, Oza A, Clarke B, Cohen B, Reedjik M, et al.
Invest New Drugs
. 2013 Jul;
31(5):1182-91.
PMID: 23860641
Background: To determine the recommended phase II dose (RP2D) and assess the safety, pharmacokinetics (PKs) and pharmacodynamics of RO4929097in combination with temsirolimus. Methods: Escalating doses of RO4929097 and temsirolimus were...
6.
Richter S, Bedard P, Chen E, Clarke B, Tran B, Hotte S, et al.
Invest New Drugs
. 2013 May;
32(2):243-9.
PMID: 23645447
Purpose: To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of...
7.
Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M
Cancer Res
. 2011 Jan;
71(1):277-86.
PMID: 21199807
Aberrant activation of the Notch receptor signaling pathway and overexpression of the Notch ligand JAG1 are associated with poor outcome in breast cancer. The plasminogen activator system, which includes urokinase-type...
8.
Cohen B, Shimizu M, Izrailit J, Ng N, Buchman Y, Pan J, et al.
Breast Cancer Res Treat
. 2009 Nov;
123(1):113-24.
PMID: 19915977
The Notch ligand, JAG1 is associated with breast cancer recurrence. Herein, we report on a genomics approach to elucidate mechanisms downstream of JAG1 that promote breast cancer growth. In a...
9.
Baliko F, Bright T, Poon R, Cohen B, Egan S, Alman B
Am J Pathol
. 2007 Apr;
170(5):1686-94.
PMID: 17456774
Cells from Ewing sarcoma exhibit cellular features and express markers, suggesting that the tumor is of neuroectodermal origin. Because Notch signaling regulates the differentiation of neuroectodermal cells during development, we...