Brenda A Schulman
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Explore the profile of Brenda A Schulman including associated specialties, affiliations and a list of published articles.
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174
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11763
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Recent Articles
11.
Horn-Ghetko D, Hopf L, Tripathi-Giesgen I, Du J, Kostrhon S, Vu D, et al.
Nat Struct Mol Biol
. 2024 Apr;
31(7):1083-1094.
PMID: 38605244
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, 'cullin-RING' and 'RBR', are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes...
12.
Adolf F, Du J, Goodall E, Walsh Jr R, Rawson S, von Gronau S, et al.
Nat Struct Mol Biol
. 2024 Apr;
31(8):1176-1188.
PMID: 38600324
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here we report cryo-electron microscopy reconstructions of seven...
13.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585873
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
14.
Gross A, Muller J, Chrustowicz J, Strasser A, Gottemukkala K, Sherpa D, et al.
FEBS Lett
. 2024 Apr;
598(9):978-994.
PMID: 38575527
Patients with Skraban-Deardorff syndrome (SKDEAS), a neurodevelopmental syndrome associated with a spectrum of developmental and intellectual delays and disabilities, harbor diverse mutations in WDR26, encoding a subunit of the multiprotein...
15.
Hoyer M, Capitanio C, Smith I, Paoli J, Bieber A, Jiang Y, et al.
Nat Cell Biol
. 2024 Mar;
26(3):378-392.
PMID: 38429475
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in...
16.
Li J, Purser N, Liwocha J, Scott D, Byers H, Steigenberger B, et al.
Mol Cell
. 2024 Feb;
84(7):1304-1320.e16.
PMID: 38382526
Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly separated. Substrates are recognized by substrate receptors, such...
17.
Adolf F, Du J, Goodall E, Walsh Jr R, Rawson S, von Gronau S, et al.
bioRxiv
. 2024 Feb;
PMID: 38328185
Dedicated assembly factors orchestrate stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here, we report cryo-EM reconstructions of seven recombinant human...
18.
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist D, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(2):378-389.
PMID: 38326650
E3 ubiquitin ligases, in collaboration with E2 ubiquitin-conjugating enzymes, modify proteins with poly-ubiquitin chains. Cullin-RING ligase (CRL) E3s use Cdc34/UBE2R-family E2s to build Lys48-linked poly-ubiquitin chains to control an enormous...
19.
Botsch J, Junker R, Sorgenfrei M, Ogger P, Stier L, von Gronau S, et al.
Nat Commun
. 2024 Jan;
15(1):410.
PMID: 38195637
Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we...
20.
Lewis S, Jourdain A, Schulman B, Vousden K, Fabius J, Liu H
Mol Cell
. 2024 Jan;
84(1):8-11.
PMID: 38181764
For our special issue on stress, we asked scientists about recovering from the stress of the pandemic, including some who shared insights with us in mid-2020. They discuss the importance...