Brantley R Herrin
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Explore the profile of Brantley R Herrin including associated specialties, affiliations and a list of published articles.
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31
Citations
813
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Recent Articles
1.
Joshi S, Liu J, Bloom T, Atabay E, Kuo T, Lee M, et al.
Sci Rep
. 2022 May;
12(1):7803.
PMID: 35551212
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. However,...
2.
Lajoie J, Katt M, Waters E, Herrin B, Shusta E
Sci Rep
. 2022 Apr;
12(1):6044.
PMID: 35411012
The blood-brain barrier (BBB) represents a significant bottleneck for the delivery of therapeutics to the central nervous system. In recent years, the promise of coopting BBB receptor-mediated transport systems for...
3.
McKitrick T, Hanes M, Rosenberg C, Heimburg-Molinaro J, Cooper M, Herrin B, et al.
Methods Mol Biol
. 2021 Dec;
2421:73-89.
PMID: 34870812
The jawless vertebrates (lamprey and hagfish) evolved a novel adaptive immune system with many similarities to that found in the jawed vertebrates, including the production of antigen-specific circulating antibodies in...
4.
Kumar R, Grinberg A, Li H, Kuo T, Sako D, Krishnan L, et al.
Sci Rep
. 2021 Sep;
11(1):18341.
PMID: 34526551
Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo. To obtain agents...
5.
McKitrick T, Bernard S, Noll A, Collins B, Goth C, McQuillan A, et al.
Commun Biol
. 2021 Jun;
4(1):674.
PMID: 34083726
The terminal galactose residues of N- and O-glycans in animal glycoproteins are often sialylated and/or fucosylated, but sulfation, such as 3-O-sulfated galactose (3-O-SGal), represents an additional, but poorly understood modification....
6.
McKitrick T, Goth C, Rosenberg C, Nakahara H, Heimburg-Molinaro J, McQuillan A, et al.
Commun Biol
. 2020 Mar;
3(1):91.
PMID: 32111965
Studies on the expression of cellular glycans are limited by a lack of sensitive tools that can discriminate specific structural features. Here we describe the development of a robust platform...
7.
Hassan K, Hansen J, Herrin B, Amemiya C
Biomolecules
. 2019 Dec;
9(12).
PMID: 31842457
The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes. The diversity of the molecules is generated by stepwise...
8.
Umlauf B, Clark P, Lajoie J, Georgieva J, Bremner S, Herrin B, et al.
Sci Adv
. 2019 May;
5(5):eaau4245.
PMID: 31106264
Diseases that lead to blood-brain barrier (BBB) disruption will pathologically expose normally inaccessible brain extracellular matrix (ECM) to circulating blood components. Therefore, we hypothesized that brain ECM-targeting moieties could specifically...
9.
Gunn R, Herrin B, Acharya S, Cooper M, Wilson I
J Mol Biol
. 2018 Mar;
430(9):1350-1367.
PMID: 29596914
Variable lymphocyte receptors (VLRs) are unconventional adaptive immune receptors relatively recently discovered in the phylogenetically ancient jawless vertebrates, lamprey and hagfish. VLRs bind antigens using a leucine-rich repeat fold and...
10.
Collins B, Nakahara H, Acharya S, Cooper M, Herrin B, Wilson I
Acta Crystallogr F Struct Biol Commun
. 2017 Dec;
73(Pt 12):682-687.
PMID: 29199989
Variable lymphocyte receptors (VLRs), the leucine-rich repeat (LRR)-based antigen receptors of jawless fish, have great utility in a wide variety of biochemical and biological applications, similar to classical Ig-based antibodies....