Bram Gerritsen
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Explore the profile of Bram Gerritsen including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
392
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Recent Articles
1.
Rijken R, Pameijer E, Gerritsen B, Hiddingh S, Stehouwer M, de Boer J, et al.
Exp Eye Res
. 2024 Nov;
250:110154.
PMID: 39547643
Age-related macular degeneration (AMD) remains a leading cause of vision loss in the geriatric population. There are age-related changes in peripheral blood leukocyte composition, but their significance for AMD remains...
2.
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Fourati S, Tomalin L, Mule M, Chawla D, Gerritsen B, Rychkov D, et al.
Nat Immunol
. 2022 Nov;
23(12):1777-1787.
PMID: 36316476
Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here,...
3.
Hagan T, Gerritsen B, Tomalin L, Fourati S, Mule M, Chawla D, et al.
Nat Immunol
. 2022 Nov;
23(12):1788-1798.
PMID: 36316475
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples,...
4.
Diray-Arce J, Miller H, Henrich E, Gerritsen B, Mule M, Fourati S, et al.
Sci Data
. 2022 Oct;
9(1):635.
PMID: 36266291
Vaccines are among the most cost-effective public health interventions for preventing infection-induced morbidity and mortality, yet much remains to be learned regarding the mechanisms by which vaccines protect. Systems immunology...
5.
de Greef P, Oakes T, Gerritsen B, Ismail M, Heather J, Hermsen R, et al.
Elife
. 2020 Mar;
9.
PMID: 32187010
The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive...
6.
Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar M, van Dijk D, et al.
PLoS Negl Trop Dis
. 2020 Mar;
14(3):e0008112.
PMID: 32150565
The genus Flavivirus contains many mosquito-borne human pathogens of global epidemiological importance such as dengue virus, West Nile virus, and Zika virus, which has recently emerged at epidemic levels. Infections...
7.
Gerritsen B, Pandit A, Zaaraoui-Boutahar F, van den Hout M, van IJcken W, De Boer R, et al.
Immunogenetics
. 2019 Dec;
72(1-2):101-108.
PMID: 31797007
The domestic ferret, Mustela putorius furo, is an important mammalian animal model to study human respiratory infection. However, insufficient genomic annotation hampers detailed studies of ferret T cell responses. In...
8.
Gerritsen B, Pandit A, Andeweg A, De Boer R
Bioinformatics
. 2016 Jun;
32(20):3098-3106.
PMID: 27324198
Motivation: High Throughput Sequencing (HTS) has enabled researchers to probe the human T cell receptor (TCR) repertoire, which consists of many rare sequences. Distinguishing between true but rare TCR sequences...
9.
Gerritsen B, Pandit A
Immunol Cell Biol
. 2015 Dec;
94(3):236-41.
PMID: 26700072
CD8(+) T cells have an important role in protection against infections and reinfections of intra-cellular pathogens like viruses. Naive CD8(+) T cells circulating in blood or lymphoid tissues can get...
10.
Kloverpris H, McGregor R, McLaren J, Ladell K, Harndahl M, Stryhn A, et al.
J Immunol
. 2015 Apr;
194(11):5329-45.
PMID: 25911754
Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen. In the case of CD8(+) T cells,...