Bradley W Biggs
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Explore the profile of Bradley W Biggs including associated specialties, affiliations and a list of published articles.
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12
Citations
91
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Recent Articles
1.
Biggs B, Price M, Lai D, Escobedo J, Fortanel Y, Huang Y, et al.
Mol Syst Biol
. 2024 Oct;
20(11):1207-1229.
PMID: 39375541
Our ability to predict, control, or design biological function is fundamentally limited by poorly annotated gene function. This can be particularly challenging in non-model systems. Accordingly, there is motivation for...
2.
Biggs B, de Paz A, Bhan N, Cybulski T, Church G, Tyo K
ACS Synth Biol
. 2023 Oct;
12(11):3301-3311.
PMID: 37856140
Advancements in synthetic biology have provided new opportunities in biosensing, with applications ranging from genetic programming to diagnostics. Next generation biosensors aim to expand the number of accessible environments for...
3.
Biggs B, Tyo K
bioRxiv
. 2023 Sep;
PMID: 37662333
Achieving sustainable chemical synthesis and a circular economy will require process innovation to minimize or recover existing waste streams. Valorization of lignin biomass has the ability to advance this goal....
4.
Biggs B, Alper H, Pfleger B, Tyo K, Santos C, Ajikumar P, et al.
Science
. 2021 Dec;
374(6575):1563-1565.
PMID: 34941395
Commercial-scale research translation has been muted.
5.
Arvay E, Biggs B, Guerrero L, Jiang V, Tyo K
Metab Eng Commun
. 2021 Aug;
13:e00173.
PMID: 34430203
Utilization of lignin, an abundant renewable resource, is limited by its heterogenous composition and complex structure. Biological valorization of lignin provides advantages over traditional chemical processing as it occurs at...
6.
Glasscock C, Biggs B, Lazar J, Arnold J, Burdette L, Valdes A, et al.
ACS Synth Biol
. 2021 Apr;
10(5):1199-1213.
PMID: 33834762
One major challenge in synthetic biology is the deleterious impacts of cellular stress caused by expression of heterologous pathways, sensors, and circuits. Feedback control and dynamic regulation are broadly proposed...
7.
Vogl T, Kickenweiz T, Pitzer J, Sturmberger L, Weninger A, Biggs B, et al.
Nat Commun
. 2021 Feb;
12(1):1287.
PMID: 33602905
No abstract available.
8.
Biggs B, Bedore S, Arvay E, Huang S, Subramanian H, McIntyre E, et al.
Nucleic Acids Res
. 2020 Apr;
48(9):5169-5182.
PMID: 32246719
One primary objective of synthetic biology is to improve the sustainability of chemical manufacturing. Naturally occurring biological systems can utilize a variety of carbon sources, including waste streams that pose...
9.
Love A, Biggs B, Tyo K, Ajikumar P
Methods Mol Biol
. 2019 Feb;
1927:37-45.
PMID: 30788784
Chemically inducible chromosomal evolution (CIChE) was developed for stable multicopy chromosomal integration of heterologous genes. In this technique, flanking an antibiotic selection marker and a gene of interest with identical...
10.
Vogl T, Kickenweiz T, Pitzer J, Sturmberger L, Weninger A, Biggs B, et al.
Nat Commun
. 2018 Oct;
9(1):4566.
PMID: 30374035
The original version of this Article was updated after publication to add the ORCID ID of the author Thomas Vogl, which was inadvertently omitted, and to include a corrected version...