Keith E J Tyo
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Explore the profile of Keith E J Tyo including associated specialties, affiliations and a list of published articles.
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56
Citations
1339
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Recent Articles
1.
Carlson C, Loveless T, Milisavljevic M, Kelly P, Mills J, Tyo K, et al.
ACS Synth Biol
. 2024 Sep;
13(10):3326-3343.
PMID: 39302688
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase capable of template-independent extension of DNA. TdT's DNA synthesis ability has found utility in DNA recording, DNA data storage, oligonucleotide synthesis,...
2.
Milisavljevic M, Rodriguez T, Tyo K
Biotechnol Bioeng
. 2024 Sep;
121(12):3808-3821.
PMID: 39275897
Harnessing DNA as a high-density storage medium for information storage and molecular recording of signals has been of increasing interest in the biotechnology field. Recently, progress in enzymatic DNA synthesis,...
3.
Milisavljevic M, Rodriguez T, Carlson C, Liu C, Tyo K
ACS Synth Biol
. 2024 Jul;
13(8):2492-2504.
PMID: 39083642
Enzymatic DNA writing technologies based on the template-independent DNA polymerase terminal deoxynucleotidyl transferase (TdT) have the potential to advance DNA information storage. TdT is unique in its ability to synthesize...
4.
Carlson C, Loveless T, Milisavljevic M, Kelly P, Mills J, Tyo K, et al.
bioRxiv
. 2024 Jun;
PMID: 38915690
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase capable of template-independent extension of DNA with random nucleotides. TdT's DNA synthesis ability has found utility in DNA recording, DNA data...
5.
Callisto A, Strutz J, Leeper K, Kalhor R, Church G, Tyo K, et al.
bioRxiv
. 2024 May;
PMID: 38765976
High resolution cellular signal encoding is critical for better understanding of complex biological phenomena. DNA-based biosignal encoders alter genomic or plasmid DNA in a signal dependent manner. Current approaches involve...
6.
Biggs B, de Paz A, Bhan N, Cybulski T, Church G, Tyo K
ACS Synth Biol
. 2023 Oct;
12(11):3301-3311.
PMID: 37856140
Advancements in synthetic biology have provided new opportunities in biosensing, with applications ranging from genetic programming to diagnostics. Next generation biosensors aim to expand the number of accessible environments for...
7.
Biggs B, Tyo K
bioRxiv
. 2023 Sep;
PMID: 37662333
Achieving sustainable chemical synthesis and a circular economy will require process innovation to minimize or recover existing waste streams. Valorization of lignin biomass has the ability to advance this goal....
8.
Shebek K, Strutz J, Broadbelt L, Tyo K
BMC Bioinformatics
. 2023 Mar;
24(1):106.
PMID: 36949401
Background: Biochemical reaction prediction tools leverage enzymatic promiscuity rules to generate reaction networks containing novel compounds and reactions. The resulting reaction networks can be used for multiple applications such as...
9.
Martin J, Rasor B, DeBonis J, Karim A, Jewett M, Tyo K, et al.
Metab Eng
. 2023 Feb;
76:133-145.
PMID: 36724840
Cell-free systems are useful tools for prototyping metabolic pathways and optimizing the production of various bioproducts. Mechanistically-based kinetic models are uniquely suited to analyze dynamic experimental data collected from cell-free...
10.
Strutz J, Shebek K, Broadbelt L, Tyo K
Bioinformatics
. 2022 May;
38(13):3484-3487.
PMID: 35595247
Summary: Although advances in untargeted metabolomics have made it possible to gather data on thousands of cellular metabolites in parallel, identification of novel metabolites from these datasets remains challenging. To...