Boris Zinshteyn
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Explore the profile of Boris Zinshteyn including associated specialties, affiliations and a list of published articles.
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26
Citations
2174
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Recent Articles
1.
Foged M, Recazens E, Chollet S, Lisci M, Allen G, Zinshteyn B, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2414187121.
PMID: 39503847
Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a...
2.
Venkatesh A, McKenty T, Ali S, Sonntag D, Ravipaty S, Cui Y, et al.
Nucleic Acid Ther
. 2024 Sep;
34(5):221-233.
PMID: 39264859
Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy most frequently associated with mutations. Most variants result in haploinsufficiency, and patient cells express roughly half of the normal levels...
3.
Hao Y, Hulscher R, Zinshteyn B, Woodson S
bioRxiv
. 2024 Jan;
PMID: 38260533
The production of new ribosomes requires proper folding of the rRNA and the addition of more than 50 ribosomal proteins. The structures of some assembly intermediates have been determined by...
4.
Koller T, Scheid U, Kosel T, Herrmann J, Krug D, Boshoff H, et al.
J Am Chem Soc
. 2023 Jan;
145(2):851-863.
PMID: 36603206
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin...
5.
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation
Niederer R, Rojas-Duran M, Zinshteyn B, Gilbert W
Cell Syst
. 2022 Jan;
13(3):256-264.e3.
PMID: 35041803
Translational control shapes the proteome in normal and pathophysiological conditions. Current high-throughput approaches reveal large differences in mRNA-specific translation activity but cannot identify the causative mRNA features. We developed direct...
6.
Zinshteyn B, Sinha N, Enam S, Koleske B, Green R
PLoS Genet
. 2021 Oct;
17(10):e1009813.
PMID: 34665823
Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered...
7.
Enam S, Zinshteyn B, Goldman D, Cassani M, Livingston N, Seydoux G, et al.
Elife
. 2020 Aug;
9.
PMID: 32844748
Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains from translating ribosomes. Puromycin has been used in molecular biology research for decades as a...
8.
Sinha N, Ordureau A, Best K, Saba J, Zinshteyn B, Sundaramoorthy E, et al.
Elife
. 2020 Aug;
9.
PMID: 32744497
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to...
9.
Limbrick E, Graf M, Derewacz D, Nguyen F, Spraggins J, Wieland M, et al.
J Am Chem Soc
. 2020 Jul;
142(43):18369-18377.
PMID: 32709196
Many microorganisms possess the capacity for producing multiple antibiotic secondary metabolites. In a few notable cases, combinations of secondary metabolites produced by the same organism are used in important combination...
10.
Wu C, Peterson A, Zinshteyn B, Regot S, Green R
Cell
. 2020 Jul;
182(2):404-416.e14.
PMID: 32610081
Problems arising during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality control events. However, the global cellular response to ribosome collisions has not...