Boris Lenhard
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Explore the profile of Boris Lenhard including associated specialties, affiliations and a list of published articles.
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154
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Recent Articles
1.
Adlakha A, Williams T, Shou X, Reed A, Lenhard B, Armstrong-James D
iScience
. 2025 Feb;
28(2):111535.
PMID: 39898039
Invasive pulmonary aspergillosis is a lethal opportunistic fungal infection in transplant recipients receiving calcineurin inhibitors. We previously identified a role for the calcineurin pathway in innate immune responses to and...
2.
Lopez-Noriega L, Callingham R, Martinez-Sanchez A, Nawaz S, Pizza G, Haberman N, et al.
iScience
. 2025 Jan;
28(1):111518.
PMID: 39811653
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of beta cell function. Here, we show that an lncRNA-transcribed antisense to Pax6, annotated as Pax6os1/PAX6-AS1, was upregulated by high glucose...
3.
Murphy A, Askarova A, Lenhard B, Skene N, Marzi S
Nucleic Acids Res
. 2024 Dec;
53(4).
PMID: 39660643
To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based on large-scale machine learning models. However, these approaches have omitted...
4.
Haberman N, Digby H, Faraway R, Cheung R, Chakrabarti A, Jobbins A, et al.
BMC Biol
. 2024 Nov;
22(1):254.
PMID: 39511645
The 3' untranslated region (3'UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped...
5.
Rauluseviciute I, Launay T, Barzaghi G, Nikumbh S, Lenhard B, Krebs A, et al.
Nucleic Acids Res
. 2024 Sep;
52(18):e85.
PMID: 39217462
Transcription factor (TF) binding to DNA is critical to transcription regulation. Although the binding properties of numerous individual TFs are well-documented, a more detailed comprehension of how TFs interact cooperatively...
6.
Haberman N, Cheung R, Pizza G, Cvetesic N, Nagy D, Maude H, et al.
FASEB J
. 2024 Aug;
38(16):e23885.
PMID: 39139039
Liver kinase B1 (LKB1/STK11) is an important regulator of pancreatic β-cell identity and function. Elimination of Lkb1 from the β-cell results in improved glucose-stimulated insulin secretion and is accompanied by...
7.
Haberman N, Cheung R, Pizza G, Cvetesic N, Nagy D, Maude H, et al.
bioRxiv
. 2024 May;
PMID: 38798508
Liver kinase B1 (LKB1/STK11) is an important regulator of pancreatic β-cell identity and function. Elimination of from the β-cell results in improved glucose-stimulated insulin secretion and is accompanied by profound...
8.
Pavlu S, Nikumbh S, Kovacik M, An T, Lenhard B, Simkova H, et al.
Comput Struct Biotechnol J
. 2024 Jan;
23:264-277.
PMID: 38173877
Precise localization and dissection of gene promoters are key to understanding transcriptional gene regulation and to successful bioengineering applications. The core RNA polymerase II initiation machinery is highly conserved among...
9.
Nikumbh S, Lenhard B
PLoS Comput Biol
. 2023 Nov;
19(11):e1011491.
PMID: 37983292
Core promoters are stretches of DNA at the beginning of genes that contain information that facilitates the binding of transcription initiation complexes. Different functional subsets of genes have core promoters...
10.
Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon J, Ferenc K, Kumar V, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D174-D182.
PMID: 37962376
JASPAR (https://jaspar.elixir.no/) is a widely-used open-access database presenting manually curated high-quality and non-redundant DNA-binding profiles for transcription factors (TFs) across taxa. In this 10th release and 20th-anniversary update, the CORE...