Bogdan A Luca
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Explore the profile of Bogdan A Luca including associated specialties, affiliations and a list of published articles.
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9
Citations
2342
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Recent Articles
1.
Ediriwickrema A, Nakauchi Y, Fan A, Kohnke T, Hu X, Luca B, et al.
bioRxiv
. 2024 May;
PMID: 38766031
Hematopoietic multipotent progenitors (MPPs) regulate blood cell production to appropriately meet the biological demands of the human body. Human MPPs remain ill-defined whereas mouse MPPs have been well characterized with...
2.
Sayitoglu E, Luca B, Boss A, Thomas B, Freeborn R, Uyeda M, et al.
Leukemia
. 2024 May;
38(6):1246-1255.
PMID: 38724673
T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples are resistant to killing by...
3.
Subramanian A, Nemat-Gorgani N, Ellis-Caleo T, van IJzendoorn D, Sears T, Somani A, et al.
Nat Cancer
. 2024 Mar;
5(4):642-658.
PMID: 38429415
Characterization of the diverse malignant and stromal cell states that make up soft tissue sarcomas and their correlation with patient outcomes has proven difficult using fixed clinical specimens. Here, we...
4.
Sayitoglu E, Luca B, Boss A, Thomas B, Freeborn R, Uyeda M, et al.
bioRxiv
. 2023 Oct;
PMID: 37790561
Significance: AML is a common leukemia with sub-optimal outcomes. We show that AML transcriptional programs correlate with susceptibility to T cell killing. Killing resistance-associated AML programs are enriched in patients...
5.
Steen C, Luca B, Alizadeh A, Gentles A, Newman A
Methods Mol Biol
. 2023 Mar;
2629:43-71.
PMID: 36929073
Tissues are composed of diverse cell types and cellular states that organize into distinct ecosystems with specialized functions. EcoTyper is a collection of machine learning tools for the large-scale delineation...
6.
Lozano A, Chaudhuri A, Nene A, Bacchiocchi A, Earland N, Vesely M, et al.
Nat Med
. 2022 Jan;
28(2):353-362.
PMID: 35027754
Severe immune-related adverse events (irAEs) occur in up to 60% of patients with melanoma treated with immune checkpoint inhibitors (ICIs). However, it is unknown whether a common baseline immunological state...
7.
Steen C, Luca B, Esfahani M, Azizi A, Sworder B, Nabet B, et al.
Cancer Cell
. 2021 Oct;
39(10):1422-1437.e10.
PMID: 34597589
Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-origin subtypes and associated genomic lesions, but also by diverse cell types and cell states in the...
8.
Luca B, Steen C, Matusiak M, Azizi A, Varma S, Zhu C, et al.
Cell
. 2021 Oct;
184(21):5482-5496.e28.
PMID: 34597583
Determining how cells vary with their local signaling environment and organize into distinct cellular communities is critical for understanding processes as diverse as development, aging, and cancer. Here we introduce...
9.
Newman A, Steen C, Liu C, Gentles A, Chaudhuri A, Scherer F, et al.
Nat Biotechnol
. 2019 May;
37(7):773-782.
PMID: 31061481
Single-cell RNA-sequencing has emerged as a powerful technique for characterizing cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be applied to fixed specimens collected as...