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Ravindra Majeti

Explore the profile of Ravindra Majeti including associated specialties, affiliations and a list of published articles. Areas
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Articles 141
Citations 13648
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Recent Articles
1.
Allen B, Bottomly D, Kohnke T, Wang A, Lin H, Johnson K, et al.
Blood . 2025 Feb; PMID: 40009487
MDM2 inhibitors are promising therapeutics for acute myeloid leukemia (AML) with wild-type TP53. Through an integrated analysis of functional genomic data from primary patient samples, we found that an MDM2...
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Hilgart E, Zhou W, Martinez-Montes E, Idrizi A, Tryggvadottir R, Gondek L, et al.
bioRxiv . 2024 Nov; PMID: 39554147
Disruption of the epigenetic landscape is of particular interest in acute myeloid leukemia (AML) due to its relatively low mutational burden and frequent occurrence of mutations in epigenetic regulators. Here,...
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Kohnke T, Karigane D, Hilgart E, Fan A, Kayamori K, Miyauchi M, et al.
bioRxiv . 2024 Nov; PMID: 39553934
Genetic mutations are being thoroughly mapped in human cancers, yet a fundamental question in cancer biology is whether such mutations are functionally required for cancer initiation, maintenance of established cancer,...
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Kohnke T, Feng Y, Majeti R
Exp Hematol . 2024 Oct; 140:104652. PMID: 39362578
Functional experimentation has laid the foundation for our understanding of hematopoietic and leukemic stem cells. Yet, most recently, a flurry of descriptive studies of primary human cells, fueled by rapid...
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Boutelle A, Mabene A, Yao D, Xu H, Wang M, Tang Y, et al.
bioRxiv . 2024 Sep; PMID: 39345444
, the most frequently mutated gene in human cancer, encodes a transcriptional activator that induces myriad downstream target genes. Despite the importance of p53 in tumor suppression, the specific p53...
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Aakash F, Gisriel S, Zeidan A, Bennett J, Bejar R, Bewersdorf J, et al.
Mod Pathol . 2024 Sep; 37(12):100615. PMID: 39322118
Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of biologically distinct entities characterized by variable degrees of ineffective hematopoiesis. Recently, 2 classification systems (the 5th edition of the World Health Organization...
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Ediriwickrema A, Nakauchi Y, Fan A, Kohnke T, Hu X, Luca B, et al.
bioRxiv . 2024 May; PMID: 38766031
Hematopoietic multipotent progenitors (MPPs) regulate blood cell production to appropriately meet the biological demands of the human body. Human MPPs remain ill-defined whereas mouse MPPs have been well characterized with...
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Amaya L, Abe B, Liu J, Zhao F, Zhang W, Chen R, et al.
Mol Cell . 2024 May; 84(11):2104-2118.e6. PMID: 38761795
Circular RNAs (circRNAs) are stable RNAs present in cell-free RNA, which may comprise cellular debris and pathogen genomes. Here, we investigate the phenomenon and mechanism of cellular uptake and intracellular...
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Sayitoglu E, Luca B, Boss A, Thomas B, Freeborn R, Uyeda M, et al.
Leukemia . 2024 May; 38(6):1246-1255. PMID: 38724673
T cells are important for the control of acute myeloid leukemia (AML), a common and often deadly malignancy. We observed that some AML patient samples are resistant to killing by...