Bogdan-Tiberius Preca
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Explore the profile of Bogdan-Tiberius Preca including associated specialties, affiliations and a list of published articles.
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12
Citations
475
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Recent Articles
1.
Amante R, Jehanno C, De Silva D, Coissieux M, Ackerknecht M, Romanet V, et al.
J Mammary Gland Biol Neoplasia
. 2023 Jun;
28(1):13.
PMID: 37294349
The protein tyrosine phosphatase SHP2 activates oncogenic pathways downstream of most receptor tyrosine kinases (RTK) and has been implicated in various cancer types, including the highly aggressive subtype of triple-negative...
2.
Auf der Maur P, Trefny M, Baumann Z, Vulin M, Correia A, Diepenbruck M, et al.
Cell Rep Med
. 2023 Apr;
4(4):101002.
PMID: 37044095
A genome-wide PiggyBac transposon-mediated screen and a resistance screen in a PIK3CA-mutated murine tumor model reveal NF1 loss in mammary tumors resistant to the phosphatidylinositol 3-kinase α (PI3Kα)-selective inhibitor alpelisib....
3.
Vulin M, Jehanno C, Sethi A, Correia A, Obradovic M, Couto J, et al.
Oncogene
. 2022 Aug;
41(39):4459-4473.
PMID: 36008466
Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast cancer, the subtype triple-negative lacks expression of major differentiation markers, e.g., estrogen receptor α (ERα), and its high...
4.
Jolly M, Preca B, Tripathi S, Jia D, George J, Hanash S, et al.
APL Bioeng
. 2019 May;
2(3):031908.
PMID: 31069317
Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating capacity. EMT is not always a binary process; rather, cells...
5.
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, et al.
Nat Struct Mol Biol
. 2019 May;
26(5):361-371.
PMID: 31061526
Histone lysine methylation is generally performed by SET domain methyltransferases and regulates chromatin structure and gene expression. Here, we identify human C21orf127 (HEMK2, N6AMT1, PrmC), a member of the seven-β-strand...
6.
Oria V, Lopatta P, Schmitz T, Preca B, Nystrom A, Conrad C, et al.
Mol Oncol
. 2018 Dec;
13(2):456-479.
PMID: 30556643
A disintegrin and a metalloprotease (ADAM)-9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC)...
7.
Metzger E, Stepputtis S, Strietz J, Preca B, Urban S, Willmann D, et al.
Cancer Res
. 2017 Sep;
77(21):5900-5912.
PMID: 28883001
Traditional treatments for breast cancer fail to address therapy-resistant cancer stem-like cells that have been characterized by changes in epigenetic regulators such as the lysine demethylase KDM4. Here, we describe...
8.
Preca B, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, et al.
Oncotarget
. 2017 Jan;
8(7):11530-11543.
PMID: 28086235
Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from the primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT is mediated by key transcription factors,...
9.
ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
Strietz J, Stepputtis S, Preca B, Vannier C, Kim M, Castro D, et al.
Oncotarget
. 2016 Nov;
7(50):83278-83293.
PMID: 27829216
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular...
10.
Preca B, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, et al.
Int J Cancer
. 2015 Jun;
137(11):2566-77.
PMID: 26077342
Invasion and metastasis of carcinomas are often activated by induction of aberrant epithelial-mesenchymal transition (EMT). This is mainly driven by the transcription factor ZEB1, promoting tumor-initiating capacity correlated with increased...