Eric Metzger
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Explore the profile of Eric Metzger including associated specialties, affiliations and a list of published articles.
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51
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3265
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Recent Articles
1.
Jia Y, Wang S, Urban S, Muller J, Sum M, Wang Q, et al.
Nat Commun
. 2025 Jan;
16(1):1191.
PMID: 39885202
Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identify lysine methyltransferase (KMT)9 as a regulator of PDC...
2.
Seitz J, Auth M, Prinz T, Hau M, Tzortzoglou P, Schulz-Fincke J, et al.
Arch Pharm (Weinheim)
. 2024 Jul;
357(10):e2400450.
PMID: 39004853
Epigenetic modulators such as lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) are drug targets for cancer, neuropsychiatric disease, or inflammation, but inhibitors of these enzymes exhibit considerable side effects....
3.
Colcerasa A, Friedrich F, Melesina J, Moser P, Vogelmann A, Tzortzoglou P, et al.
J Med Chem
. 2024 Jun;
67(12):10076-10095.
PMID: 38847803
The NAD-dependent lysine deacylase sirtuin 2 (Sirt2) is involved in multiple pathological conditions such as cancer. Targeting Sirt2 has thus received an increased interest for therapeutic purposes. Furthermore, the orthologue...
4.
Totonji S, Ramos-Triguero A, Willmann D, Sum M, Urban S, Bauer H, et al.
Cancers (Basel)
. 2024 Apr;
16(8).
PMID: 38672614
Novel treatment modalities are imperative for the challenging management of muscle-invasive and metastatic BC to improve patient survival rates. The recently identified KMT9, an obligate heterodimer composed of KMT9α and...
5.
Cai Q, Sahu R, Ueberschlag-Pitiot V, Souali-Crespo S, Charvet C, Silem I, et al.
Nat Commun
. 2024 Apr;
15(1):3563.
PMID: 38670969
Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities...
6.
Wang S, Klein S, Urban S, Staudt M, Barthes N, Willmann D, et al.
Nat Commun
. 2024 Jan;
15(1):43.
PMID: 38167811
Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer....
7.
Koll F, Metzger E, Hamann J, Ramos-Triguero A, Bankov K, Kollermann J, et al.
Cells
. 2023 Feb;
12(4).
PMID: 36831256
Muscle-invasive bladder cancer (MIBC) is associated with limited response rates to systemic therapy leading to a significant risk of recurrence and death. A recently discovered histone methyltransferase KMT9, acts as...
8.
Sailer V, von Amsberg G, Duensing S, Kirfel J, Lieb V, Metzger E, et al.
Nat Rev Urol
. 2022 Nov;
20(3):158-178.
PMID: 36451039
Androgen deprivation therapy has a central role in the treatment of advanced prostate cancer, often causing initial tumour remission before increasing independence from signal transduction mechanisms of the androgen receptor...
9.
Berlin C, Cottard F, Willmann D, Urban S, Tirier S, Marx L, et al.
Cancer Res
. 2021 Nov;
82(2):210-220.
PMID: 34737213
Colorectal cancer is among the leading causes of cancer-associated deaths worldwide. Treatment failure and tumor recurrence due to survival of therapy-resistant cancer stem/initiating cells represent major clinical issues to overcome....
10.
Baumert H, Metzger E, Fahrner M, George J, Thomas R, Schilling O, et al.
Cancer Cell Int
. 2020 Feb;
20:52.
PMID: 32095117
Background: Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone...