Blair K A Willette
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Explore the profile of Blair K A Willette including associated specialties, affiliations and a list of published articles.
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7
Citations
76
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Recent Articles
1.
Klauer M, Willette B, Tsvetanova N
J Biol Chem
. 2024 Jan;
300(3):105668.
PMID: 38272232
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and a critical class of regulators of mammalian physiology. Also known as seven transmembrane receptors (7TMs), GPCRs are...
2.
Sanchez-Soto M, Boldizsar N, Schardien K, Madaras N, Willette B, Inbody L, et al.
Biomolecules
. 2023 Oct;
13(10).
PMID: 37892234
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition. β-arrestins are believed to interact...
3.
Willette B, Zhang J, Zhang J, Tsvetanova N
Nat Chem Biol
. 2023 Jul;
20(2):151-161.
PMID: 37500769
G-protein-coupled receptors (GPCRs) can initiate unique functional responses depending on the subcellular site of activation. Efforts to uncover the mechanistic basis of compartmentalized GPCR signaling have concentrated on the biochemical...
4.
Free R, Cuoco C, Xie B, Namkung Y, Prabhu V, Willette B, et al.
Mol Pharmacol
. 2021 Aug;
100(4):372-387.
PMID: 34353882
ONC201 is a first-in-class imipridone compound that is in clinical trials for the treatment of high-grade gliomas and other advanced cancers. Recent studies identified that ONC201 antagonizes D2-like dopamine receptors...
5.
Sanchez-Soto M, Kumar Verma R, Willette B, Gonye E, Moore A, Moritz A, et al.
Sci Signal
. 2020 Feb;
13(617).
PMID: 32019899
Signaling bias is the propensity for some agonists to preferentially stimulate G protein-coupled receptor (GPCR) signaling through one intracellular pathway versus another. We previously identified a G protein-biased agonist of...
6.
Willette B, Nangia A, Howard S, DiPalma D, McMillan C, Tharwani S, et al.
Pharmacol Biochem Behav
. 2019 Aug;
186:172766.
PMID: 31470021
A variety of neural systems are involved in the brain bases of tobacco addiction. Animal models of nicotine addiction have helped identify a variety of interacting neural systems involved in...
7.
Luderman K, Conroy J, Free R, Southall N, Ferrer M, Sanchez-Soto M, et al.
Mol Pharmacol
. 2018 Aug;
94(4):1197-1209.
PMID: 30068735
The D dopamine receptor is linked to a variety of neuropsychiatric disorders and represents an attractive drug target for the enhancement of cognition in schizophrenia, Alzheimer disease, and other disorders....