Blaine N Armbruster
Overview
Explore the profile of Blaine N Armbruster including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
2931
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Guettier J, Gautam D, Scarselli M, Ruiz de Azua I, Li J, Rosemond E, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(45):19197-202.
PMID: 19858481
Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The...
2.
Alexander G, Rogan S, Abbas A, Armbruster B, Pei Y, Allen J, et al.
Neuron
. 2009 Jul;
63(1):27-39.
PMID: 19607790
Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow...
3.
Nawaratne V, Leach K, Suratman N, Loiacono R, Felder C, Armbruster B, et al.
Mol Pharmacol
. 2008 Jul;
74(4):1119-31.
PMID: 18628403
The M4 muscarinic acetylcholine (ACh) receptor (mAChR) is a potential therapeutic target but characterized by a lack of subtype-selective ligands. We recently generated "designer receptors exclusively activated by a designer...
4.
Barrientos K, Kendellen M, Freibaum B, Armbruster B, Etheridge K, Counter C
Mol Cell Biol
. 2008 Jun;
28(17):5251-64.
PMID: 18519588
The mammalian protein POT1 binds to telomeric single-stranded DNA (ssDNA), protecting chromosome ends from being detected as sites of DNA damage. POT1 is composed of an N-terminal ssDNA-binding domain and...
5.
Otto J, Mulugu S, Fridy P, Chiou S, Armbruster B, Ribeiro A, et al.
Methods Enzymol
. 2007 Oct;
434:171-85.
PMID: 17954248
Lipid-derived inositol phosphates (IPs) are a complex group of second messengers generated by the sequential phosphorylation of inositol 1,4,5-trisphosphate (IP(3)). Synthetic pathways leading from IP(3) to the formation of inositol...
6.
Armbruster B, Li X, Pausch M, Herlitze S, Roth B
Proc Natl Acad Sci U S A
. 2007 Mar;
104(12):5163-8.
PMID: 17360345
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable compound (clozapine-N-oxide). Subsequent screening...
7.
Keiser M, Roth B, Armbruster B, Ernsberger P, Irwin J, Shoichet B
Nat Biotechnol
. 2007 Feb;
25(2):197-206.
PMID: 17287757
The identification of protein function based on biological information is an area of intense research. Here we consider a complementary technique that quantitatively groups and relates proteins based on the...
8.
9.
York S, Armbruster B, Greenwell P, Petes T, York J
J Biol Chem
. 2004 Nov;
280(6):4264-9.
PMID: 15561716
Activation of phospholipase C-dependent inositol polyphosphate signaling pathways generates distinct messengers derived from inositol 1,4,5-trisphosphate that control gene expression and mRNA export. Here we report the regulation of telomere length...
10.
Armbruster B, Linardic C, Veldman T, Bansal N, Downie D, Counter C
Mol Cell Biol
. 2004 Apr;
24(8):3552-61.
PMID: 15060173
The protein hPot1 shares homology with telomere-binding proteins in lower eukaryotes and associates with single-stranded telomeric DNA in vitro as well as colocalizing with telomere-binding proteins in vivo. We now...