Michael J Keiser
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Explore the profile of Michael J Keiser including associated specialties, affiliations and a list of published articles.
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47
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2766
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Recent Articles
1.
Gunsalus L, Keiser M, Pollard K
PLoS Comput Biol
. 2025 Feb;
21(2):e1012841.
PMID: 39965010
The investigation of chromatin organization in single cells holds great promise for identifying causal relationships between genome structure and function. However, analysis of single-molecule data is hampered by extreme yet...
2.
Nogueira V, Sharma R, Guido R, Keiser M
J Chem Inf Model
. 2025 Feb;
65(4):1911-1927.
PMID: 39908426
Researchers are developing increasingly robust molecular representations, motivating the need for thorough methods to stress-test and validate them. Here, we use a variational auto-encoder (VAE), an unsupervised deep learning model,...
3.
Li Y, Serras C, Blumenfeld J, Xie M, Hao Y, Deng E, et al.
bioRxiv
. 2024 Dec;
PMID: 39713353
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a cell-type-specific,...
4.
Gendelev L, Taylor J, Myers-Turnbull D, Chen S, McCarroll M, Arkin M, et al.
Nat Commun
. 2024 Nov;
15(1):9955.
PMID: 39551797
Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screen a library of 650 central nervous system active compounds...
5.
Muir D, Asper G, Notin P, Posner J, Marks D, Keiser M, et al.
bioRxiv
. 2024 Nov;
PMID: 39484523
Quantitatively mapping enzyme sequence-catalysis landscapes remains a critical challenge in understanding enzyme function, evolution, and design. Here, we expand an emerging microfluidic platform to measure catalytic constants- and -for hundreds...
6.
Ghandian S, Albarghouthi L, Nava K, Sharma S, Minaud L, Beckett L, et al.
bioRxiv
. 2024 Oct;
PMID: 39386601
Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of Alzheimer disease (AD). Accurate detection of NFTs in tissue samples can reveal relationships with clinical, demographic,...
7.
Hall B, Keiser M
J Chem Inf Model
. 2024 Oct;
64(19):7398-7408.
PMID: 39360680
Make-on-demand chemical libraries have drastically increased the reach of molecular docking, with the enumerated ready-to-dock ZINC-22 library approaching 6.4 billion molecules (July 2024). While ever-growing libraries result in better-scoring molecules,...
8.
Connell W, Garcia K, Goodarzi H, Keiser M
Commun Biol
. 2024 Sep;
7(1):1149.
PMID: 39278951
Chemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge,...
9.
Gale-Day Z, Shub L, Chuang K, Keiser M
J Chem Inf Model
. 2024 Jul;
64(14):5439-5450.
PMID: 38953560
Message passing neural networks (MPNNs) on molecular graphs generate continuous and differentiable encodings of small molecules with state-of-the-art performance on protein-ligand complex scoring tasks. Here, we describe the proximity graph...
10.
Vizcarra J, Pearce T, Dugger B, Keiser M, Gearing M, Crary J, et al.
Acta Neuropathol Commun
. 2023 Dec;
11(1):202.
PMID: 38110981
Machine learning (ML) has increasingly been used to assist and expand current practices in neuropathology. However, generating large imaging datasets with quality labels is challenging in fields which demand high...