Author: Bita Shakoory

1.

Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome

Carcillo J, Shakoory B

Adv Exp Med Biol . 2024 Aug; 1448:441-457. PMID: 39117832

There is extensive overlap of clinical features among familial or primary HLH (pHLH), reactive or secondary hemophagocytic lymphohistiocytosis (sHLH) [including macrophage activation syndrome (MAS) related to rheumatic diseases], and hyperferritinemic...

2.

The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS)

Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, et al.

Ann Rheum Dis . 2023 Jul; 82(10):1271-1285. PMID: 37487610

Objective: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can develop in most inflammatory contexts. They can progress rapidly, and early identification and management...

3.

The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS)

Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, et al.

Arthritis Rheumatol . 2023 Jul; 75(10):1714-1732. PMID: 37486733

Objective: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can develop in most inflammatory contexts. They can progress rapidly, and early identification and management...

4.

Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation

Anderko R, Gomez H, Canna S, Shakoory B, Angus D, Yealy D, et al.

Intensive Care Med Exp . 2022 Feb; 10(1):6. PMID: 35190900

Background: Interleukin-1 receptor antagonists can reduce mortality in septic shock patients with hepatobiliary dysfunction and disseminated intravascular coagulation (HBD + DIC), an organ failure pattern with inflammatory features consistent with...

5.

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults

Hines M, von Bahr Greenwood T, Beutel G, Beutel K, Hays J, Horne A, et al.

Crit Care Med . 2021 Oct; 50(5):860-872. PMID: 34605776

Objective: Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome that often requires critical care support and remains difficult to diagnose. These guidelines are meant to aid in the early recognition, diagnosis, supportive...

6.

An immune-based biomarker signature is associated with mortality in COVID-19 patients

Abers M, Delmonte O, Ricotta E, Fintzi J, Fink D, de Jesus A, et al.

JCI Insight . 2020 Nov; 6(1). PMID: 33232303

Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict...

7.

Understanding Disseminated Intravascular Coagulation and Hepatobiliary Dysfunction Multiple Organ Failure in Hyperferritinemic Critical Illness

Carcillo J, Shakoory B, Simon D, Kernan K

Pediatr Crit Care Med . 2018 Oct; 19(10):1006-1009. PMID: 30281573

No abstract available.

8.

Adults with septic shock and extreme hyperferritinemia exhibit pathogenic immune variation

Kernan K, Ghaloul-Gonzalez L, Shakoory B, Kellum J, Angus D, Carcillo J

Genes Immun . 2018 Jul; 20(6):520-526. PMID: 29977033

Post-hoc subgroup analysis of the negative trial of interleukin-1β receptor antagonist (IL1RA) for septic shock suggested that patients with features of macrophage activation syndrome (MAS) experienced a 50% relative risk...

9.

Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome

Carcillo J, Halstead E, Hall M, Nguyen T, Reeder R, Aneja R, et al.

Pediatr Crit Care Med . 2017 Apr; 18(6):513-523. PMID: 28410274

Objectives: We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis....

10.

A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis

Carcillo J, Sward K, Halstead E, Telford R, Jimenez-Bacardi A, Shakoory B, et al.

Pediatr Crit Care Med . 2016 Dec; 18(2):143-150. PMID: 27941423

Objectives: We tested the hypothesis that a C-reactive protein and ferritin-based systemic inflammation contingency table can track mortality risk in pediatric severe sepsis. Design: Prospective cohort study. Setting: Tertiary PICU....