Birgit Wiltschi
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Explore the profile of Birgit Wiltschi including associated specialties, affiliations and a list of published articles.
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44
Citations
371
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Recent Articles
1.
Kolanovic D, Pasupuleti R, Wallner J, Mlynek G, Wiltschi B
Bioconjug Chem
. 2024 Dec;
35(12):1944-1958.
PMID: 39625149
The analysis of protein-bound glycans has gained significant attention due to their pivotal roles in physiological and pathological processes like cell-cell recognition, immune response, and disease progression. Routine methods for...
2.
Hanaee-Ahvaz H, Baumann M, Tauer C, Albrecht B, Wiltschi B, Cserjan-Puschmann M, et al.
Sci Rep
. 2024 Oct;
14(1):25375.
PMID: 39455661
Protein engineering with non-canonical amino acids (ncAAs) holds great promises for diverse applications, however, there are still limitations in the implementation of this technology at manufacturing scale. The know-how to...
3.
Terzani F, Wang C, Rostami S, Desmet R, Snella B, Senechal M, et al.
STAR Protoc
. 2024 Oct;
5(4):103390.
PMID: 39412993
The development of fast ligation chemistries for the site-specific modification of proteins has become a major focus in chemical biology. We describe steps for preparing an oxalyl thioester precursor in...
4.
Hanaee-Ahvaz H, Cserjan-Puschmann M, Mayer F, Tauer C, Albrecht B, Furtmuller P, et al.
Heliyon
. 2023 Dec;
9(12):e22463.
PMID: 38046162
Functionalization of proteins by incorporating reactive non-canonical amino acids (ncAAs) has been widely applied for numerous biological and therapeutic applications. The requirement not to lose the intrinsic properties of these...
5.
Pasupuleti R, Riedl S, Saltor Nunez L, Karava M, Kumar V, Kourist R, et al.
Protein Sci
. 2023 Nov;
32(12):e4830.
PMID: 37916438
Targeted killing of tumor cells while protecting healthy cells is the pressing priority in cancer treatment. Lectins that target a specific glycan marker abundant in cancer cells can be valuable...
6.
Pasupuleti R, Rosato F, Kolanovic D, Makshakova O, Romer W, Wiltschi B
N Biotechnol
. 2023 May;
76:127-137.
PMID: 37257818
Antibody-based cancer therapies have been evolving at a rapid pace in the pharmaceutical market. Bispecific antibody-drug conjugates that engage immune cells to target and kill cancer cells with precision have...
7.
Danielewicz N, Rosato F, Tomisch J, Graber J, Wiltschi B, Striedner G, et al.
ACS Omega
. 2023 May;
8(17):15406-15421.
PMID: 37151527
In recent years, receptor-mediated drug delivery has gained major attention in the treatment of cancer. The pathogen-derived Shiga Toxin B subunit (STxB) can be used as a carrier that detects...
8.
Jodlbauer J, Rieder L, Glieder A, Wiltschi B
Methods Mol Biol
. 2023 Jan;
2617:75-86.
PMID: 36656517
In this chapter, we present a bidirectional promoter library toolbox to evaluate fast and efficiently the optimal conditions for the balanced co-expression of two target genes. As a proof-of-concept, we...
9.
Rosato F, Pasupuleti R, Tomisch J, Melendez A, Kolanovic D, Makshakova O, et al.
J Transl Med
. 2022 Dec;
20(1):578.
PMID: 36494671
Background: Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids...
10.
Tobola F, Wiltschi B
Biotechnol Adv
. 2022 Jul;
60:108020.
PMID: 35868512
Carbohydrates are more than an energy-storage. They are ubiquitously found on cells and most proteins, where they encode biological information. Lectins bind these carbohydrates and are essential for translating the...