Birgit Leitinger
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Explore the profile of Birgit Leitinger including associated specialties, affiliations and a list of published articles.
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44
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2610
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Recent Articles
1.
Sawant M, Wang F, Koester J, Niehoff A, Nava M, Lundgren-Akerlund E, et al.
Ann Rheum Dis
. 2023 Jul;
82(11):1474-1486.
PMID: 37479494
Objectives: Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce...
2.
Borza C, Bolas G, Zhang X, Monroe M, Zhang M, Meiler J, et al.
Front Cell Dev Biol
. 2022 Mar;
10:836797.
PMID: 35309920
Integrins and discoidin domain receptors (DDRs) 1 and 2 promote cell adhesion and migration on both fibrillar and non fibrillar collagens. Collagen I contains DDR and integrin selective binding motifs;...
3.
4.
Juskaite V, Leitinger B
Bio Protoc
. 2021 Mar;
9(16):e3339.
PMID: 33654844
The discoidin domain receptors, DDR1 and DDR2, are key signaling receptors for the extracellular matrix protein collagen. The interactions of cells with collagen are difficult to study because of the...
5.
Sammon D, Hohenester E, Leitinger B
Proc Natl Acad Sci U S A
. 2020 Aug;
117(36):22051-22060.
PMID: 32839343
Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase with important functions in organogenesis and tissue homeostasis. Aberrant DDR1 activity contributes to the progression of human diseases, including...
6.
Auguste P, Leitinger B, Liard C, Rocher V, Azema L, Saltel F, et al.
J Cell Sci
. 2020 Feb;
133(4).
PMID: 32094286
For the first time, a meeting dedicated to the tyrosine kinase receptors DDR1 and DDR2 took place in Bordeaux, a famous and historical city in the south of France. Over...
7.
Jalan A, Sammon D, Hartgerink J, Brear P, Stott K, Hamaia S, et al.
Nat Chem Biol
. 2020 Jan;
16(4):423-429.
PMID: 31907373
The most abundant member of the collagen protein family, collagen I (also known as type I collagen; COL1), is composed of one unique (chain B) and two similar (chain A)...
8.
Corcoran D, Juskaite V, Xu Y, Gorlitz F, Alexandrov Y, Dunsby C, et al.
Sci Rep
. 2019 Nov;
9(1):17104.
PMID: 31745115
The collagen receptor DDR1 is a receptor tyrosine kinase that promotes progression of a wide range of human disorders. Little is known about how ligand binding triggers DDR1 kinase activity....
9.
Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch J, et al.
Cell Rep
. 2019 Mar;
26(13):3672-3683.e7.
PMID: 30917320
Glioblastoma (GBM) is highly refractory to therapy and associated with poor clinical outcome. Here, we reveal a critical function of the promitotic and adhesion-mediating discoidin domain receptor 1 (DDR1) in...
10.
Malcor J, Juskaite V, Gavriilidou D, Hunter E, Davidenko N, Hamaia S, et al.
Biomaterials
. 2018 Aug;
182:21-34.
PMID: 30099278
Collagen-based scaffolds may require chemical crosslinking to achieve mechanical properties suitable for tissue engineering. Carbodiimide treatment, often used for this purpose, consumes amino acid side chains required for receptor recognition,...