Birgit E Scharf
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Explore the profile of Birgit E Scharf including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
677
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Recent Articles
1.
Esteves N, Scharf B
Sci Rep
. 2024 Jul;
14(1):17750.
PMID: 39085460
Serratia marcescens is an opportunistic human pathogen that produces a vibrant red pigment called prodigiosin. Prodigiosin has implications in virulence of S. marcescens and promising clinical applications. We discovered that...
2.
Agbekudzi A, Arapov T, Stock A, Scharf B
Mol Microbiol
. 2024 Jul;
122(4):429-446.
PMID: 39081077
Sinorhizobium meliloti senses nutrients and compounds exuded from alfalfa host roots and coordinates an excitation, termination, and adaptation pathway during chemotaxis. We investigated the role of the novel S. meliloti...
3.
Agbekudzi A, Scharf B
Mol Microbiol
. 2024 May;
122(1):50-67.
PMID: 38798055
Sensory adaptation in bacterial chemotaxis is mediated by posttranslational modifications of methyl-accepting chemotaxis proteins (MCPs). In Escherichia coli, the adaptation proteins CheR and CheB tether to a conserved C-terminal receptor...
4.
Sonani R, Esteves N, Scharf B, Egelman E
Structure
. 2024 Apr;
32(7):856-865.e3.
PMID: 38614087
The flagellotropic bacteriophage χ (Chi) infects bacteria via the flagellar filament. Despite years of study, its structural architecture remains partly characterized. Through cryo-EM, we unveil χ's nearly complete structure, encompassing...
5.
Sobe R, Scharf B
Mol Microbiol
. 2024 Mar;
121(5):954-970.
PMID: 38458990
The flagellar motor is a powerful macromolecular machine used to propel bacteria through various environments. We determined that flagellar motility of the alpha-proteobacterium Sinorhizobium meliloti is nearly abolished in the...
6.
Sonani R, Palmer L, Esteves N, Horton A, Sebastian A, Kelly R, et al.
Nat Commun
. 2024 Jan;
15(1):756.
PMID: 38272938
A contractile sheath and rigid tube assembly is a widespread apparatus used by bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell membranes. In this mechanism, contraction...
7.
Sonani R, Esteves N, Horton A, Kelly R, Sebastian A, Wang F, et al.
Commun Biol
. 2023 Sep;
6(1):921.
PMID: 37684529
Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the "neck" region, where the DNA-filled capsid is...
8.
Esteves N, Bigham D, Scharf B
PLoS Pathog
. 2023 Aug;
19(8):e1011537.
PMID: 37535496
The bacterial flagellum is a rotary motor organelle and important virulence factor that propels motile pathogenic bacteria, such as Salmonella enterica, through their surroundings. Bacteriophages, or phages, are viruses that...
9.
Salar S, Ball N, Baaziz H, Nix J, Sobe R, Compton K, et al.
Proteins
. 2023 May;
91(10):1394-1406.
PMID: 37213073
Chemotaxis is a fundamental process whereby bacteria seek out nutrient sources and avoid harmful chemicals. For the symbiotic soil bacterium Sinorhizobium meliloti, the chemotaxis system also plays an essential role...
10.
Kreutzberger M, Sonani R, Liu J, Chatterjee S, Wang F, Sebastian A, et al.
Cell
. 2022 Sep;
185(19):3487-3500.e14.
PMID: 36057255
The supercoiling of bacterial and archaeal flagellar filaments is required for motility. Archaeal flagellar filaments have no homology to their bacterial counterparts and are instead homologs of bacterial type IV...