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Birgit Brandmeier

Explore the profile of Birgit Brandmeier including associated specialties, affiliations and a list of published articles. Areas
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Citations 614
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Recent Articles
1.
Rees M, Nikoopour R, Fukuzawa A, Kho A, Fernandez-Garcia M, Wraige E, et al.
Acta Neuropathol . 2021 Jan; 141(3):431-453. PMID: 33449170
Mutations in the sarcomeric protein titin, encoded by TTN, are emerging as a common cause of myopathies. The diagnosis of a TTN-related myopathy is, however, often not straightforward due to...
2.
Sevrieva I, Brandmeier B, Ponnam S, Gautel M, Irving M, Campbell K, et al.
J Biol Chem . 2020 Feb; 295(14):4398-4410. PMID: 32086378
Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain (RLC) phosphorylation has been studied extensively and , the precise role of...
3.
Cullup T, Kho A, Dionisi-Vici C, Brandmeier B, Smith F, Urry Z, et al.
Nat Genet . 2012 Dec; 45(1):83-7. PMID: 23222957
Vici syndrome is a recessively inherited multisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. To investigate the molecular basis of Vici syndrome, we carried out exome...
4.
Puchner E, Alexandrovich A, Kho A, Hensen U, Schafer L, Brandmeier B, et al.
Proc Natl Acad Sci U S A . 2008 Sep; 105(36):13385-90. PMID: 18765796
Biological responses to mechanical stress require strain-sensing molecules, whose mechanically induced conformational changes are relayed to signaling cascades mediating changes in cell and tissue properties. In vertebrate muscle, the giant...
5.
Sun Y, Brandmeier B, Irving M
Proc Natl Acad Sci U S A . 2006 Nov; 103(47):17771-6. PMID: 17101992
Contraction of skeletal and cardiac muscle is regulated by Ca2+ -dependent structural changes in troponin that control the interaction between myosin and actin. We measured the orientations of troponin domains...
6.
Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, et al.
Science . 2005 Apr; 308(5728):1599-603. PMID: 15802564
The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1...