Biplab Dasgupta
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Explore the profile of Biplab Dasgupta including associated specialties, affiliations and a list of published articles.
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47
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5446
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Recent Articles
1.
Behrmann C, Ennis K, Sarma P, Wetzel C, Clark N, Von Handorf K, et al.
Cancer Res Commun
. 2024 Aug;
4(8):2215-2227.
PMID: 39087397
Significance: Therapy for glioblastoma would be advanced by incorporating molecularly targeted kinase-directed agents, similar to standard of care strategies in other tumor types. Here, we identify a kinase targeting approach...
2.
Oatman N, Gawali M, Congrove S, Caceres R, Sukumaran A, Gupta N, et al.
Cancer Res
. 2024 Jun;
84(14):2333-2351.
PMID: 38885087
The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to restrict the availability of key nutrients to tumors....
3.
Karve A, Desai J, Gadgil S, Dave N, Wise-Draper T, Gudelsky G, et al.
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542190
A glioblastoma (GBM) is one of the most aggressive, infiltrative, and treatment-resistant malignancies of the central nervous system (CNS). The current standard of care for GBMs include maximally safe tumor...
4.
Desai P, Karve A, Zawit M, Arora P, Dave N, Awosika J, et al.
Clin Cancer Res
. 2024 Mar;
30(10):2068-2077.
PMID: 38530160
Purpose: High-grade gliomas (HGG) carry a poor prognosis, with glioblastoma accounting for almost 50% of primary brain malignancies in the elderly. Unfortunately, despite the use of multiple treatment modalities, the...
5.
Malawsky D, Dismuke T, Liu H, Castellino E, Brenman J, Dasgupta B, et al.
iScience
. 2023 Dec;
26(12):108443.
PMID: 38094249
We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist...
6.
Karve A, Desai J, Dave N, Wise-Draper T, Gudelsky G, Phoenix T, et al.
Cancer Chemother Pharmacol
. 2022 Sep;
90(4):345-356.
PMID: 36050497
Purpose: The DNA alkylating agent temozolomide (TMZ), is the first-line therapeutic for the treatment of glioblastoma (GBM). However, its use is confounded by the occurrence of drug resistance and debilitating...
7.
Desai J, Karve A, Gudelsky G, Gawali M, Seibel W, Sallans L, et al.
Invest New Drugs
. 2022 Jul;
40(5):944-952.
PMID: 35802287
Purpose: Emerging evidence suggests that 5' Adenosine Monophosphate-Activated Protein Kinase (AMPK), a key regulator of cellular bioenergetics, is a novel target for the treatment of glioblastoma (GBM), a lethal brain...
8.
Muraleedharan R, Dasgupta B
FEBS J
. 2021 Aug;
289(8):2247-2262.
PMID: 34355526
The adenosine monophosphate-activated protein kinase (AMPK) is an integrative metabolic sensor that maintains energy balance at the cellular level and plays an important role in orchestrating intertissue metabolic signaling. AMPK...
9.
Muraleedharan R, Nardini D, Waclaw R, Dasgupta B
STAR Protoc
. 2021 Mar;
2(1):100375.
PMID: 33718893
Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in response to all CNS injuries. Here, we present a revised hybridization and immunohistochemistry (IHC) protocol to label the...
10.
Oatman N, Dasgupta N, Arora P, Choi K, Gawali M, Gupta N, et al.
Sci Adv
. 2021 Feb;
7(7.
PMID: 33568479
The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a therapeutic target in cancer. Here, we...