Binhua Lv
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Explore the profile of Binhua Lv including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
53
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0
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Recent Articles
1.
Zhang Y, Zhou H, Suo S, Zhuang J, Yang L, He A, et al.
Blood Cancer J
. 2024 Dec;
14(1):216.
PMID: 39695117
To compare the efficacy and safety of gecacitinib (also known as jaktinib) with hydroxyurea (HU) in treating myelofibrosis (MF) patients. In this multicenter, randomized phase 3 trial (ZGJAK016), intermediate- or...
2.
Ma S, Yi L, Bian Y, Lv B, Zhang C, Li C, et al.
Cancer Chemother Pharmacol
. 2024 Dec;
95(1):5.
PMID: 39673613
Purpose: The study aims to investigate the absorption, metabolism, and excretion of donafenib, a deuterated derivative of sorafenib, in healthy Chinese male volunteers. Methods: Six healthy Chinese male volunteers were...
3.
Dai T, Sun H, Liban T, Vicente-Suarez I, Zhang B, Song Y, et al.
Sci Rep
. 2024 May;
14(1):10661.
PMID: 38724599
We report the generation of a novel anti-LAG-3/TIGIT bispecific IgG4 antibody, ZGGS15, and evaluated its anti-tumor efficacy in mouse models as monotherapy or in combination with a PD-1 antibody. ZGGS15...
4.
Pang X, Cui D, Lv B, Wang C
J Med Chem
. 2024 Jan;
67(2):1563-1579.
PMID: 38206836
Directly targeted KRAS inhibitors are now facing resistance problems, which might be partially solved by the combination of SOS1 inhibitors with KRAS inhibitors. However, this combination may still have some...
5.
Study on Typical Diarylurea Drugs or Derivatives in Cocrystallizing with Strong H-Bond Acceptor DMSO
Li C, Zhong J, Liu B, Yang T, Lv B, Luo Y
ACS Omega
. 2021 Mar;
6(8):5532-5547.
PMID: 33681594
Diarylureas are widely used in self-assembly and supramolecular chemistry owing to their outstanding characteristics as both H-bond donors and acceptors. Unfortunately, this bonding property is rarely applied in the development...
6.
Liu J, Lv B, Yin H, Zhu X, Wei H, Ding Y
Front Pharmacol
. 2021 Feb;
11:604314.
PMID: 33536914
Jaktinib is a novel selective janus kinase 1/2 inhibitor. The phase I first-in-human study evaluated the tolerance and pharmacokinetics of jaktinib in healthy Chinese subjects. A randomized, double-blind, placebo-controlled study...
7.
Xu G, Lv B, Roberge J, Xu B, Du J, Dong J, et al.
J Med Chem
. 2014 Jan;
57(4):1236-51.
PMID: 24456245
SGLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer tmax and half-life (t1/2), dose-dependent increase in urinary glucose excretion (UGE) in rats, and...
8.
Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(15):4465-70.
PMID: 21737266
A series of C-aryl glucosides with various substituents at the 4'-position of the distal aryl ring have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of alkyl...
9.
Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, et al.
Pharmacol Res
. 2011 Jan;
63(4):284-93.
PMID: 21215314
Sodium glucose co-transporter 2 (SGLT2) is a renal type III integral membrane protein that co-transports sodium and glucose from filtrate to epithelium in the proximal tubule. Human subjects with homozygous...
10.
Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, et al.
Bioorg Med Chem
. 2010 Jun;
18(12):4422-32.
PMID: 20576578
A series of 2-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to...