Bindu Chandrasekharan
Overview
Explore the profile of Bindu Chandrasekharan including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
514
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Recent Articles
1.
Chandrasekharan B, Boyer D, Owens J, Wolfarth A, Saeedi B, Dhere T, et al.
Inflamm Bowel Dis
. 2021 Nov;
28(5):815.
PMID: 34792116
No abstract available.
2.
Chandrasekharan B, Boyer D, Owens J, Wolfarth A, Saeedi B, Dhere T, et al.
Inflamm Bowel Dis
. 2021 Oct;
28(4):502-513.
PMID: 34613372
We have demonstrated that neuropeptide Y (NPY) can regulate pro-inflammatory signaling in the gut via cross-talk with the pro-inflammatory cytokine tumor necrosis factor (TNF). Here, we investigated if selective blocking...
3.
Chandrasekharan B, Neish A
J Vis Exp
. 2021 Jun;
(172).
PMID: 34180888
CLARITY (Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging compatible Tissue hYdrogel) has recently evolved as a valuable technique involving acrylamide embedding to delipidate tissue (without sectioning) and to preserve the 3-D tissue...
4.
Chandrasekharan B, Montllor-Albalate C, Colin A, Andersen J, Jang Y, Reddi A
Biochem Biophys Res Commun
. 2020 Nov;
534:720-726.
PMID: 33218686
Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O) into oxygen (O) and hydrogen peroxide (HO), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that...
5.
Wolfarth A, Liu X, Darby T, Boyer D, Spizman J, Owens J, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Jul;
10(4):713-727.
PMID: 32629119
Background & Aims: The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment from the microbial and antigenic components of the gut...
6.
Saeedi B, Liu K, Owens J, Hunter-Chang S, Camacho M, Eboka R, et al.
Cell Metab
. 2020 Mar;
31(5):956-968.e5.
PMID: 32213347
Many studies have suggested a role for gut-resident microbes (the "gut microbiome") in modulating host health; however, the mechanisms by which they impact systemic physiology remain largely unknown. In this...
7.
Ahn E, Kang S, Liu X, Chen G, Zhang Z, Chandrasekharan B, et al.
Cell Res
. 2019 Oct;
30(1):70-87.
PMID: 31649329
Lewy pathology, composed of α-Synuclein (α-Syn) inclusions, a hallmark of Parkinson's disease (PD), progressively spreads from the enteric nervous system (ENS) to the central nervous system (CNS). However, it remains...
8.
Saeedi B, Chandrasekharan B, Neish A
Methods Mol Biol
. 2019 Jun;
1982:329-337.
PMID: 31172482
Reactive oxygen species (ROS) are potent signaling molecules with critical roles in cellular pathology and homeostasis. They are produced in all cell types via a diverse array of cellular machinery,...
9.
Chandrasekharan B, Saeedi B, Alam A, Houser M, Srinivasan S, Tansey M, et al.
Gastroenterology
. 2019 Apr;
157(1):179-192.e2.
PMID: 30930024
Background & Aims: Reduced gastrointestinal (GI) motility is a feature of disorders associated with intestinal dysbiosis and loss of beneficial microbes. It is not clear how consumption of beneficial commensal...
10.
Montllor-Albalate C, Colin A, Chandrasekharan B, Bolaji N, Andersen J, Outten F, et al.
Redox Biol
. 2018 Dec;
21:101064.
PMID: 30576923
Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen. As a consequence, Sod1 serves dual...