Cu/Zn Superoxide Dismutase (Sod1) Regulates the Canonical Wnt Signaling Pathway

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2020 Nov 21

PMID 33218686

Citations 8

Authors

Bindu Chandrasekharan

Claudia Montllor-Albalate

Alyson E Colin

Joshua L Andersen

Young C Jang

Amit R Reddi

Affiliations

Soon will be listed here.

Abstract

Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O) into oxygen (O) and hydrogen peroxide (HO), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an HO-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O, Sod1-derived HO stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation.

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