Bimolendu Das
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Explore the profile of Bimolendu Das including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
68
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Recent Articles
1.
Blaszczyk L, Ryczek M, Das B, Mateja-Pluta M, Bejger M, Sliwiak J, et al.
Nucleic Acids Res
. 2024 May;
52(11):6707-6717.
PMID: 38738637
The abnormal expansion of GGGGCC/GGCCCC hexanucleotide repeats (HR) in C9orf72 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Structural polymorphisms of HR result in the multifactorial pathomechanism...
2.
Das B, Nagano K, Kawai G, Murata A, Nakatani K
J Org Chem
. 2021 Dec;
87(1):340-350.
PMID: 34937340
Small molecules targeting DNA regions with structural fluctuation are an important class of molecule as chemical probes for studying the role of these structures in biological systems and the development...
3.
Das B, Murata A, Nakatani K
Nucleic Acids Res
. 2021 Aug;
49(15):8462-8470.
PMID: 34358308
Small-molecules interacting with particular RNAs and modulating their functions are vital tools for RNA-targeting drug discovery. Considering the substantial distribution of the internal loops involving two contiguous cytosines opposite to...
4.
Murata A, Mori Y, Di Y, Sugai A, Das B, Takashima Y, et al.
Biochemistry
. 2021 Jan;
60(4):245-249.
PMID: 33476116
MicroRNAs are potential targets for drug development. Small molecules that can inhibit or promote a specific miRNA's biogenesis would be useful for regulating its target genes. Various types of small...
5.
Nakatani K, Natsuhara N, Mori Y, Mukherjee S, Das B, Murata A
Chem Asian J
. 2017 Nov;
12(23):3077-3087.
PMID: 29094805
One of the important determinants in the efficiency of a molecular interaction is the necessity for conformational changes in host and/or guest molecules upon binding. In small-molecule interactions with nucleic...
6.
Jash M, Das B, Chowdhury C
J Org Chem
. 2016 Oct;
81(22):10987-10999.
PMID: 27779864
A Pd(II)-catalyzed direct synthesis of benzo[a]carbazoles has been achieved through aminopalladation of alkynes, followed by intramolecular nucleophilic addition of the generated carbon-palladium bond to a tethered cyano/aldehyde group. Compared to...
7.
Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, et al.
PLoS One
. 2015 Oct;
10(10):e0139657.
PMID: 26436418
Background: Current chemotherapeutic agents based on apoptosis induction are lacking in desired efficacy. Therefore, there is continuous effort to bring about new dimension in control and gradual eradication of cancer...
8.
Das B, Kundu P, Chowdhury C
Org Biomol Chem
. 2013 Dec;
12(5):741-8.
PMID: 24346629
A facile method for the general synthesis of 2-arylmethylindoles has been developed through the reaction of 2-(2-propynyl)aniline or 2-(2-propynyl)tosylanilide with aryl iodides in the presence of Pd(OAc)2, PPh3, and DBU....
9.
Chowdhury C, Das B, Mukherjee S, Achari B
J Org Chem
. 2012 May;
77(11):5108-19.
PMID: 22616775
A facile and efficient method for the synthesis of (E)-2-arylmethylidene-N-tosylindolines and (E)-2-arylmethylidene-N-tosyl/nosyltetrahydroquinoline variants has been developed through palladium-catalyzed cyclocondensation of aryl iodides with readily available 1-(2-tosylaminophenyl)prop-2-yn-1-ols and their higher homologues,...
10.
Das B, Chowdhury C, Kumar D, Sen R, Roy R, Das P, et al.
Bioorg Med Chem Lett
. 2010 Oct;
20(23):6947-50.
PMID: 20974534
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a,...