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Bhaskar C Das

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Articles 53
Citations 911
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Recent Articles
1.
Zhang X, Subbanna S, Williams C, Canals-Baker S, Hashim A, Wilson D, et al.
Molecules . 2025 Feb; 30(3). PMID: 39942725
Methionine aminopeptidase 2 (MetAP2) plays an important role in the regulation of protein synthesis and post-translational processing. Preclinical/clinical applications of MetAP2 inhibitors for the treatment of various diseases have been...
2.
Das B, Chokkalingam P, Shareef M, Shukla S, Das S, Saito M, et al.
J Eukaryot Microbiol . 2024 Jul; 71(5):e13036. PMID: 39036929
Methionine aminopeptidases (MetAPs) have emerged as a target for medicinal chemists in the quest for novel therapeutic agents for treating cancer, obesity, and other disorders. Methionine aminopeptidase is a metalloenzyme...
3.
Saito M, Subbanna S, Zhang X, Canals-Baker S, Smiley J, Wilson D, et al.
Front Neurosci . 2023 May; 17:1170259. PMID: 37205047
Ethanol exposure in neonatal mice induces acute neurodegeneration followed by long-lasting glial activation and GABAergic cell deficits along with behavioral abnormalities, providing a third trimester model of fetal alcohol spectrum...
4.
Das B, Lepe J, Shareef M, Lomeli N, Das S, Bota D
Bioorg Med Chem Lett . 2023 May; 91:129330. PMID: 37201660
In continuation of our previous efforts for the development of potent small molecules against brain cancer, herein we synthesized seventeen new compounds and tested their anti-gliomapotential against established glioblastoma cell...
5.
Zhang X, Subbanna S, Williams C, Canals-Baker S, Smiley J, Wilson D, et al.
Neurochem Res . 2023 Feb; 48(6):1958-1970. PMID: 36781685
BT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group. Previous studies indicated that activation of retinoic acid (RA) signaling may attenuate progression of...
6.
Das B, Yadav P, Das S, Saito M, Evans T
Molecules . 2023 Feb; 28(3). PMID: 36770721
Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed...
7.
Das B, Chokkalingam P, Masilamani P, Shukla S, Das S
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36769081
Drug delivery systems, which use components at the nanoscale level as diagnostic tools or to release therapeutic drugs to particular target areas in a regulated manner, are a fast-evolving field...
8.
Das B, Yadav P, Das S, He J
RSC Adv . 2022 Sep; 12(37):24187-24191. PMID: 36128533
Herein, we demonstrate a Pd catalyzed C-4 borylation of structurally complex chloroquinolines with bis(pinacolato)diboron under relatively simple and efficient conditions. Moreover, the borylated quinolines were converted into oxaborole, trifluoroborate salt...
9.
Das B, Nandwana N, Ojha D, Das S, Evans T
Tetrahedron Lett . 2022 Aug; 92. PMID: 35935920
Herein, we report the design, synthesis and application of a borylated amidoxime reagent for the direct synthesis of functionalized oxadiazole and quinazolinone derivatives. This reagent exhibits broad synthetic utility to...
10.
Nandwana V, Nandwana N, Das Y, Saito M, Panda T, Das S, et al.
Molecules . 2022 Jun; 27(11). PMID: 35684340
Hundreds of billions of commensal microorganisms live in and on our bodies, most of which colonize the gut shortly after birth and stay there for the rest of our lives....