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Betty Benton

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Recent Articles
1.
Andres D, Keyser B, Benton B, Melber A, Olivera D, Holmes W, et al.
Toxicol Lett . 2015 Nov; 244:21-27. PMID: 26562769
Phosgene (CG), a toxic inhalation and industrial hazard, causes bronchoconstriction, vasoconstriction and associated pathological effects that could be life threatening. Ion channels of the transient receptor potential (TRP) family have...
2.
Kanjilal B, Keyser B, Andres D, Nealley E, Benton B, Melber A, et al.
Toxicol Mech Methods . 2014 Jul; 24(7):488-94. PMID: 25045830
The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in...
3.
Keyser B, Andres D, Holmes W, Paradiso D, Appell A, Letukas V, et al.
Int J Toxicol . 2014 May; 33(4):271-281. PMID: 24801489
Mustard gas (sulfur mustard [SM], bis-[2-chloroethyl] sulfide) is a vesicating chemical warfare agent and a potential chemical terrorism agent. Exposure of SM causes debilitating skin blisters (vesication) and injury to...
4.
Andres D, Keyser B, Petrali J, Benton B, Hubbard K, McNutt P, et al.
BMC Neurosci . 2013 Apr; 14:49. PMID: 23597229
Background: Immortalized neuronal cell lines can be induced to differentiate into more mature neurons by adding specific compounds or growth factors to the culture medium. This property makes neuronal cell...
5.
Keyser B, Andres D, Nealley E, Holmes W, Benton B, Paradiso D, et al.
J Pharmacol Exp Ther . 2012 Nov; 344(1):308-16. PMID: 23129783
Sulfur mustard (SM) is a vesicant chemical warfare and terrorism agent. Besides skin and eye injury, respiratory damage has been mainly responsible for morbidity and mortality after SM exposure. Previously,...
6.
Ray R, Simbulan-Rosenthal C, Keyser B, Benton B, Anderson D, Holmes W, et al.
Toxicology . 2010 Mar; 271(3):94-9. PMID: 20226831
Sulfur mustard (SM [bis-(2-chloroethyl) sulfide]) is a chemical warfare agent that causes skin blisters presumably due to DNA alkylation and cross-links. We recently showed that SM also induces apoptotic death...
7.
Ray R, Keyser B, Benton B, Daher A, Simbulan-Rosenthal C, Rosenthal D
Drug Chem Toxicol . 2007 Dec; 31(1):137-48. PMID: 18161513
We have shown that sulfur mustard (SM; bis-(2-chloroethyl) sulfide), an alkylating, vesicating chemical warfare agent, causes dermal toxicity, including skin microblisters, via the induction of both death receptor (DR) and...
8.
Simbulan-Rosenthal C, Ray R, Benton B, Soeda E, Daher A, Anderson D, et al.
Toxicology . 2006 Aug; 227(1-2):21-35. PMID: 16935404
Sulfur mustard (SM) causes blisters in the skin through a series of cellular changes that we are beginning to identify. We earlier demonstrated that SM toxicity is the result of...
9.
Ray R, Hauck S, Kramer R, Benton B
Drug Chem Toxicol . 2005 Feb; 28(1):105-16. PMID: 15720039
Sulfur mustard [SM; bis-(2-chloroethyl) sulfide], which causes skin blistering or vesication [(1991). Histo- and cytopathology of acute epithelial lesions. In: Papirmeister, B., Feister, A. J., Robinson, S. I., Ford, R....
10.
Rosenthal D, Velena A, Chou F, Schlegel R, Ray R, Benton B, et al.
J Biol Chem . 2002 Dec; 278(10):8531-40. PMID: 12482751
DNA damaging agents up-regulate levels of the Fas receptor or its ligand, resulting in recruitment of Fas-associated death domain (FADD) and autocatalytic activation of caspase-8, consequently activating the executioner caspases-3,...