Bettina Drisaldi
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Explore the profile of Bettina Drisaldi including associated specialties, affiliations and a list of published articles.
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11
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629
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Recent Articles
1.
Drisaldi B, Colnaghi L, Levine A, Huang Y, Snyder A, Metzger D, et al.
Front Cell Neurosci
. 2020 Aug;
14:207.
PMID: 32742260
A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly pleasurable experience initially associated with...
2.
Drisaldi B, Colnaghi L, Fioriti L, Rao N, Myers C, Snyder A, et al.
Cell Rep
. 2015 Jun;
11(11):1694-702.
PMID: 26074071
Protein synthesis is crucial for the maintenance of long-term-memory-related synaptic plasticity. The prion-like cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates the translation of several mRNAs important for long-term synaptic plasticity...
3.
Fioriti L, Myers C, Huang Y, Li X, Stephan J, Trifilieff P, et al.
Neuron
. 2015 Jun;
86(6):1433-48.
PMID: 26074003
Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse...
4.
Huang Y, Levine A, Kandel D, Yin D, Colnaghi L, Drisaldi B, et al.
Learn Mem
. 2014 Feb;
21(3):153-60.
PMID: 24549570
The dentate gyrus (DG) of the hippocampus is critical for spatial memory and is also thought to be involved in the formation of drug-related associative memory. Here, we attempt to...
5.
Levine A, Huang Y, Drisaldi B, Griffin Jr E, Pollak D, Xu S, et al.
Sci Transl Med
. 2011 Nov;
3(107):107ra109.
PMID: 22049069
In human populations, cigarettes and alcohol generally serve as gateway drugs, which people use first before progressing to marijuana, cocaine, or other illicit substances. To understand the biological basis of...
6.
Watts J, Drisaldi B, Ng V, Yang J, Strome B, Horne P, et al.
EMBO J
. 2007 Aug;
26(17):4038-50.
PMID: 17703189
The cellular prion protein, PrP(C), is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS-expressed Doppel or internally deleted PrP ('DeltaPrP'). This paradigm has...
7.
Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts J, et al.
J Biol Chem
. 2004 Oct;
279(53):55443-54.
PMID: 15459186
The PrP-like Doppel (Dpl) protein causes apoptotic death of cerebellar neurons in transgenic mice, a process prevented by expression of the wild type (wt) cellular prion protein, PrP(C). Internally deleted...
8.
Phinney A, Drisaldi B, Schmidt S, Lugowski S, Coronado V, Liang Y, et al.
Proc Natl Acad Sci U S A
. 2003 Nov;
100(24):14193-8.
PMID: 14617772
Cu ions have been suggested to enhance the assembly and pathogenic potential of the Alzheimer's disease amyloid-beta (Abeta) peptide. To explore this relationship in vivo, toxic-milk (txJ) mice with a...
9.
Chiesa R, Piccardo P, Quaglio E, Drisaldi B, Si-Hoe S, Takao M, et al.
J Virol
. 2003 Jun;
77(13):7611-22.
PMID: 12805461
Tg(PG14) mice express a prion protein (PrP) with a nine-octapeptide insertion associated with a human familial prion disease. These animals spontaneously develop a fatal neurodegenerative disorder characterized by ataxia, neuronal...
10.
Harris D, Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, et al.
Clin Lab Med
. 2003 May;
23(1):175-86.
PMID: 12733431
We have produced a mouse model of a familial prion disorder by introduction of a transgene that encodes the moPrP homolog of a nine-octapeptide insertional mutant associated with an inherited...