Bertrand J Jean-Claude
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Explore the profile of Bertrand J Jean-Claude including associated specialties, affiliations and a list of published articles.
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56
Citations
310
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Recent Articles
1.
Quispialaya K, Therriault J, Aliaga A, Benedet A, Ashton N, Karikari T, et al.
Neurology
. 2024 Dec;
104(2):e210211.
PMID: 39715476
Background And Objectives: To compare the diagnostic performance of an immunoassay for plasma concentrations of phosphorylated tau (p-tau) 217 with visual assessments of fluorine-18 fluorodeoxyglucose [F]FDG-PET in individuals who meet...
2.
Cogliano V, Corsini E, Fournier A, Nelson H, Sergi C, Antunes A, et al.
Lancet Oncol
. 2024 Dec;
26(1):15-16.
PMID: 39622256
No abstract available.
3.
Cohen C, Levy Y, Toscano-Rivero D, Manasherova E, Agmon-Levin N, Kenett R, et al.
Front Allergy
. 2024 Sep;
5:1395834.
PMID: 39347505
Introduction: Peanut allergy (PA) in children is a major concern. There is a need for better biological material for both diagnosis and oral immunotherapy (OIT) treatments. The unique state of...
4.
Martinez-Jaramillo E, Jamali F, Abdalbari F, Abdulkarim B, Jean-Claude B, Telleria C, et al.
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001381
Glioblastoma (GBM) is the most prevalent and advanced malignant primary brain tumor in adults. GBM frequently harbors epidermal growth factor receptor (EGFR) wild-type () gene amplification and/or activating mutation. EGFR-driven...
5.
Cohen C, Mazer B, Jean-Claude B
Molecules
. 2024 Jan;
29(1).
PMID: 38202743
Higher rates of peanut allergy have been observed in countries that commonly roast peanuts prior to consumption. Despite the importance of understanding the role of thermal processing in allergy and...
6.
Facchin C, Fraga-Timiraos A, Schmitt J, Babaa N, Pannu N, Aliaga A, et al.
Cells
. 2023 Mar;
12(6).
PMID: 36980255
: ZR2002 is a dual EGFR-DNA-targeting combi-molecule that carries a chloroethyl group at the six-position of the quinazoline ring designed to alkylate DNA. Despite its good pharmacokinetics, ZR2002 is metabolized...
7.
Rao S, Thibault B, Peyrard L, Larroque-Lombard A, Rupp M, Thauvin C, et al.
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502481
The median-effect principle proposed by Chou and Talalay is the most effective approach to parameterize interactions between several agents in combination. However, this method cannot be used to evaluate the...
8.
Golabi N, Larroque A, Peyrard L, Williams C, Jean-Claude B
Invest New Drugs
. 2020 Jul;
39(1):240-250.
PMID: 32648119
To enhance the potency of EGFR inhibitors, we developed a novel strategy that seeks to conjugate EGFR to a bioactive moiety leading to a molecule termed "combi-molecule". In order to...
9.
Schmitt J, Huang S, Goodfellow E, Williams C, Jean-Claude B
J Med Chem
. 2020 Jun;
63(11):5752-5762.
PMID: 32484346
Resistance to chemotherapy in advanced cancers can be mediated by different factors such as epidermal growth factor receptor (EGFR) overexpression and DNA repair enzymes. Therefore, current standards of care usually...
10.
Schmitt J, Goodfellow E, Huang S, Williams C, Gomes I, Rosa M, et al.
Eur J Med Chem
. 2020 Mar;
192:112185.
PMID: 32145644
Over the past decade, we described a novel tumour targeted approach that sought to design "combi-molecules" to hit two distinct targets in tumour cells. Here, to generate small combi-molecules with...