Bernd J Thiele
Overview
Explore the profile of Bernd J Thiele including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
251
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Recent Articles
1.
Fahling M, Mrowka R, Steege A, Kirschner K, Benko E, Forstera B, et al.
J Biol Chem
. 2008 Dec;
284(7):4255-66.
PMID: 19097999
Fragile X syndrome is a common inherited cause of mental retardation that results from loss or mutation of the fragile X mental retardation protein (FMRP). In this study, we identified...
2.
Ufer C, Wang C, Fahling M, Schiebel H, Thiele B, Billett E, et al.
Genes Dev
. 2008 Jul;
22(13):1838-50.
PMID: 18593884
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is a moonlighting selenoprotein, which has been implicated in basic cell functions such as anti-oxidative defense, apoptosis, and gene expression regulation. GPx4-null mice die in...
3.
Steege A, Fahling M, Paliege A, Bondke A, Kirschner K, Martinka P, et al.
Kidney Int
. 2008 May;
74(4):458-66.
PMID: 18496514
Renin plays a crucial role in the control of various physiological processes such as blood pressure and body fluid homeostasis. Here, we show that a splice variant of the Wilms'...
4.
Mrowka R, Steege A, Kaps C, Herzel H, Thiele B, Persson P, et al.
Nucleic Acids Res
. 2007 Jul;
35(15):5120-9.
PMID: 17660193
Elucidating the mechanisms of the human transcriptional regulatory network is a major challenge of the post-genomic era. One important aspect is the identification and functional analysis of regulatory elements in...
5.
Fahling M, Mrowka R, Steege A, Nebrich G, Perlewitz A, Persson P, et al.
J Biol Chem
. 2006 Jul;
281(36):26089-101.
PMID: 16837461
Hypoxia is a pro-fibrotic stimulus, which is associated with enhanced collagen synthesis, as well as with augmented collagen prolyl 4-hydroxylase (C-P4H) activity. C-P4H activity is controlled mainly by regulated expression...
6.
Fahling M, Mrowka R, Steege A, Martinka P, Persson P, Thiele B
J Biol Chem
. 2006 Feb;
281(14):9279-86.
PMID: 16464861
Collagen prolyl 4-hydroxylase (C-P4H) alpha-subunit is of regulatory importance in the assembling of C-P4H tetramers, which are necessary for the hydroxylation of procollagen chains. Change in collagen expression by hypoxia...
7.
Fahling M, Steege A, Perlewitz A, Nafz B, Mrowka R, Persson P, et al.
Biochim Biophys Acta
. 2005 Sep;
1731(1):32-40.
PMID: 16153722
Matrix-metalloproteinases (MMPs), which are able to degrade extra cellular matrix (ECM) components, are crucial in ECM-remodeling, under physiological (e.g., embryogenesis, wound healing, angiogenesis) or pathophysiological conditions (e.g., arthritis, cancer progression...
8.
Bachmann S, Mutig K, Bates J, Welker P, Geist B, Gross V, et al.
Am J Physiol Renal Physiol
. 2004 Nov;
288(3):F559-67.
PMID: 15522986
The Tamm-Horsfall protein (THP; uromodulin), the dominant protein in normal urine, is produced exclusively in the thick ascending limb of Henle's loop. THP mutations are associated with disease; however, the...