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Bernardo Ramirez-Zavala

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Citations 322
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Recent Articles
1.
Ramirez-Zavala B, Hoffmann A, Kruger I, Schwanfelder S, Barker K, Rogers P, et al.
mSphere . 2024 Jun; 9(7):e0038824. PMID: 38940507
Importance: is one of the medically most important fungi and a model organism to study fungal pathogenicity. Investigating gene function in this diploid yeast has been facilitated by the adaptation...
2.
Ramirez-Zavala B, Kruger I, Schwanfelder S, Barker K, Rogers P, Morschhauser J
mSphere . 2024 Jun; 9(7):e0027024. PMID: 38860767
Importance: Transcription factors are central regulators of gene expression, and knowledge about which transcription factor regulates specific genes in response to a certain signal is important to understand the behavior...
3.
Ramirez-Zavala B, Betsova D, Schwanfelder S, Kruger I, Mottola A, Kruger T, et al.
mSphere . 2023 Nov; 8(6):e0054623. PMID: 38010000
The SNF1 protein kinase signaling pathway, which is highly conserved in eukaryotic cells, is important for metabolic adaptations in the pathogenic yeast . However, so far, it has remained elusive...
4.
Oneissi M, Cruz M, Ramirez-Zavala B, Lindemann-Perez E, Morschhauser J, Garsin D, et al.
PLoS Pathog . 2023 Sep; 19(9):e1011692. PMID: 37769015
The signals that denote mammalian host environments and dictate the activation of signaling pathways in human-associated microorganisms are often unknown. The transcription regulator Rtg1/3 in the human fungal pathogen Candida...
5.
Ramirez-Zavala B, Kruger I, Wollner A, Schwanfelder S, Morschhauser J
PLoS Genet . 2023 Aug; 19(8):e1010890. PMID: 37561787
Protein kinases are central components of almost all signaling pathways that control cellular activities. In the model organism Saccharomyces cerevisiae, the paralogous protein kinases Ypk1 and Ypk2, which control membrane...
6.
Raschig M, Ramirez-Zavala B, Wiest J, Saedtler M, Gutmann M, Holzgrabe U, et al.
Arch Pharm (Weinheim) . 2022 Nov; 356(2):e2200463. PMID: 36403201
Increasing resistance against antimycotic drugs challenges anti-infective therapies today and contributes to the mortality of infections by drug-resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising...
7.
Brandt P, Gerwien F, Wagner L, Kruger T, Ramirez-Zavala B, Mirhakkak M, et al.
Front Cell Infect Microbiol . 2022 May; 12:850531. PMID: 35601106
Protein kinases play a crucial role in regulating cellular processes such as growth, proliferation, environmental adaptation and stress responses. Serine-arginine (SR) protein kinases are highly conserved in eukaryotes and regulate...
8.
Ramirez-Zavala B, Kruger I, Dunker C, Jacobsen I, Morschhauser J
PLoS Pathog . 2022 Feb; 18(2):e1010283. PMID: 35108336
Protein kinases play central roles in virtually all signaling pathways that enable organisms to adapt to their environment. Microbial pathogens must cope with severely restricted iron availability in mammalian hosts...
9.
Ramirez-Zavala B, Mottola A, Kruger I, Morschhauser J
mSphere . 2021 Dec; 6(6):e0092921. PMID: 34908458
The heterotrimeric protein kinase SNF1 is a key regulator of metabolic adaptation in the pathogenic yeast Candida albicans, and mutants with a defective SNF1 complex cannot grow on carbon sources...
10.
Omran R, Ramirez-Zavala B, Aji Tebung W, Yao S, Feng J, Law C, et al.
Genetics . 2021 Dec; 220(1). PMID: 34849863
Zinc cluster transcription factors (TFs) are essential fungal regulators of gene expression. In the pathogen Candida albicans, the gene orf19.1604 encodes a zinc cluster TF regulating filament development. Hyperactivation of...