Bernard S Buetow
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Explore the profile of Bernard S Buetow including associated specialties, affiliations and a list of published articles.
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13
Citations
129
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Recent Articles
1.
Hu W, Buetow B, Sachdeva K, Leach M
Toxicol Pathol
. 2024 Jul;
52(5):232-250.
PMID: 39049757
The toxicity of ATR-107, a human anti-interleukin-21 receptor (IL-21R) monoclonal antibody (mAb), was evaluated in CD-1 mice and cynomolgus monkeys after single-dose intravenous (IV) administration, and in Sprague-Dawley (SD) rats...
2.
Ji C, Kuang B, Buetow B, Vitsky A, Xu Y, Huang T, et al.
PLoS One
. 2024 Feb;
19(2):e0298240.
PMID: 38315680
PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and...
3.
Peraza M, Hurst S, Huang W, Buetow B, Lickteig A, Lavach J, et al.
J Ocul Pharmacol Ther
. 2023 Mar;
39(3):215-224.
PMID: 36880872
Bevacizumab-bvzr (Zirabev), a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor and a biosimilar to bevacizumab, is approved for intravenous administration for various indications worldwide. The objectives of this...
4.
Buetow B, Cappon G, Aschenbrenner L, Updyke L, Torti V, Evans M, et al.
Int J Toxicol
. 2022 Jun;
41(5):389-401.
PMID: 35672934
Bococizumab is an anti-PCSK9 monoclonal antibody that was intended for the treatment of hypercholesterolemia. After reviewing the 6-month rat toxicity study data, in which there was a low spontaneous tumor...
5.
Mathur D, Root A, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, et al.
Clin Cancer Res
. 2020 Jan;
26(9):2188-2202.
PMID: 31996389
Purpose: Gastrointestinal cancers remain areas of high unmet need despite advances in targeted and immunotherapies. Here, we demonstrate potent, tumor-selective efficacy with PF-07062119, a T-cell engaging CD3 bispecific targeting tumors...
6.
Ji C, Roy M, Golas J, Vitsky A, Ram S, Kumpf S, et al.
Clin Cancer Res
. 2019 May;
25(15):4735-4748.
PMID: 31085720
Purpose: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for...
7.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Dec;
45(8):1055-1066.
PMID: 29233079
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections...
8.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Nov;
45(8):1043-1054.
PMID: 29173114
Spontaneous rodent progressive cardiomyopathy (PCM) in the Sprague Dawley rat may confound identification and/or interpretation of potential test article (TA)-related cardiotoxicity. Pathologists apply diagnostic term(s) and thresholds for diagnosing and...
9.
Hoffmann G, Belote D, Suttie A, Buetow B, Muhumuza L
Toxicol Pathol
. 2014 Apr;
43(3):449-52.
PMID: 24692391
A sporadic, diffuse, interstitial mixed cell epididymitis of unknown etiology was noted in the epididymal cauda and distal corpus of young control Sprague-Dawley (SD) rats. Rats from 2 different suppliers...
10.
Stocking K, Jones J, Everds N, Buetow B, Roudier M, Miller R
Comp Med
. 2009 Mar;
59(1):37-45.
PMID: 19295053
Intracardiac injection of human tumor cells into anesthetized nude mice is an established model of bone metastasis. However, intracardiac injection of some human tumor cell lines cause acute neurologic signs...