Bernard E Weissman
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Explore the profile of Bernard E Weissman including associated specialties, affiliations and a list of published articles.
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47
Citations
1363
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Recent Articles
1.
Lang J, Selleck W, Striker S, Hipschman N, Kofman R, Karnezis A, et al.
iScience
. 2025 Feb;
28(2):111770.
PMID: 39906560
Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare ovarian cancer affecting young females and is driven by the loss of both SWI/SNF ATPases SMARCA4 and SMARCA2. As...
2.
Hoos E, Koval L, Corcoran D, Eaves L, Roell K, Rager J, et al.
Carcinogenesis
. 2025 Jan;
46(1).
PMID: 39873457
Endometrial cancer (EC) is the fourth most common cancer in women in the USA. Stark racial disparities are present in EC outcomes in which Black women have significantly higher EC-related...
3.
Stewart C, Diao L, Xi Y, Wang R, Ramkumar K, Serrano A, et al.
Clin Cancer Res
. 2024 Aug;
30(20):4743-4754.
PMID: 39150543
Purpose: Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine malignancy that, like small cell lung cancer (SCLC), is associated with the absence of druggable oncogenic drivers and dismal prognosis....
4.
Witherspoon J, Hall J, Jima D, Atkins H, Wamsley N, Major M, et al.
Redox Biol
. 2024 Jul;
75:103261.
PMID: 38963974
Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating...
5.
Nguyen V, Schrank T, Major M, Weissman B
PLoS One
. 2024 Feb;
19(2):e0297741.
PMID: 38358974
Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two...
6.
Hamad S, Sellers R, Wamsley N, Zolkind P, Schrank T, Major M, et al.
Cancer Res Commun
. 2024 Feb;
4(2):487-495.
PMID: 38335300
Significance: Human squamous cancers frequently show constitutive NRF2 activation, associated with poorer outcomes and resistance to multiple therapies. Here, we report the first activated NRF2-driven and human-relevant mouse model of...
7.
Zhu X, Fu Z, Chen S, Ong D, Aceto G, Ho R, et al.
Nat Commun
. 2023 May;
14(1):2894.
PMID: 37210563
SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient in either ATPase have been shown to depend...
8.
Walhart T, Vacca B, Hepperla A, Hamad S, Petrongelli J, Wang Y, et al.
Am J Pathol
. 2023 Jan;
193(4):456-473.
PMID: 36657718
Poorly differentiated (PD) chordoma, a rare, aggressive tumor originating from notochordal tissue, shows loss of SMARCB1 expression, a core component of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes. To determine...
9.
Hamad S, Montgomery S, Simon J, Bowman B, Spainhower K, Murphy R, et al.
Oncogene
. 2022 Aug;
41(39):4485.
PMID: 36002660
No abstract available.
10.
Hamad S, Montgomery S, Simon J, Bowman B, Spainhower K, Murphy R, et al.
Oncogene
. 2022 May;
41(25):3423-3432.
PMID: 35577980
Studies have shown that Nrf2 is one of the most common mutations found in human tumors. To elucidate how this genetic change contributes to lung cancer, we compared lung tumor...