Benjamin S Freedman
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Explore the profile of Benjamin S Freedman including associated specialties, affiliations and a list of published articles.
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57
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2178
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Recent Articles
11.
Taguchi K, Elias B, Sugahara S, Sant S, Freedman B, Waikar S, et al.
J Clin Invest
. 2022 Dec;
132(23).
PMID: 36453545
Acute kidney injury (AKI) occurs in approximately 13% of hospitalized patients and predisposes patients to chronic kidney disease (CKD) through the AKI-to-CKD transition. Studies from our laboratory and others have...
12.
Xu Y, Kuppe C, Perales-Paton J, Hayat S, Kranz J, Abdallah A, et al.
Nat Genet
. 2022 Oct;
54(11):1690-1701.
PMID: 36303074
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a...
13.
Cruz N, Reddy R, McFaline-Figueroa J, Tran C, Fu H, Freedman B
Nat Biomed Eng
. 2022 May;
6(9):1086.
PMID: 35610484
No abstract available.
14.
Cruz N, Reddy R, McFaline-Figueroa J, Tran C, Fu H, Freedman B
Nat Biomed Eng
. 2022 Apr;
6(4):463-475.
PMID: 35478224
The functions of cilia-antenna-like organelles associated with a spectrum of disease states-are poorly understood, particularly in human cells. Here we show that human pluripotent stem cells (hPSCs) edited via CRISPR...
15.
Hunt A, Case J, Park Y, Cao L, Wu K, Walls A, et al.
Sci Transl Med
. 2022 Apr;
14(646):eabn1252.
PMID: 35412328
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly...
16.
Freedman B
Am J Physiol Renal Physiol
. 2022 Apr;
322(6):F625-F638.
PMID: 35379001
Kidney organoids derived from human pluripotent stem cells constitute a novel model of disease, development, and regenerative therapy. Organoids are human, experimentally accessible, high throughput, and enable reconstitution of tissue-scale...
17.
Helms L, Marchiano S, Stanaway I, Hsiang T, Juliar B, Saini S, et al.
JCI Insight
. 2021 Nov;
6(24).
PMID: 34767537
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited kidney organoids and clinical data to investigate...
18.
Hunt A, Case J, Park Y, Cao L, Wu K, Walls A, et al.
bioRxiv
. 2021 Jul;
PMID: 34268509
One-sentence Summary: We designed, developed, and characterized potent, trivalent miniprotein binders that provide prophylactic and therapeutic protection against emerging SARS-CoV-2 variants of concern.
19.
Gopalan J, Omar M, Roy A, Cruz N, Falcone J, Jones K, et al.
Elife
. 2021 Jul;
10.
PMID: 34250905
Pathophysiological defects in water homeostasis can lead to renal failure. Likewise, common genetic disorders associated with abnormal cytoskeletal dynamics in the kidney collecting ducts and perturbed calcium and cAMP signaling...
20.
Wang H, Brown P, Chow E, Ewart L, Ferguson S, Fitzpatrick S, et al.
Clin Transl Sci
. 2021 May;
14(5):1659-1680.
PMID: 33982436
Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two-dimensional (2D) in vitro cell culture systems cannot...