Benjamin M Scott
Overview
Explore the profile of Benjamin M Scott including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
130
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Recent Articles
1.
Scott B, Koh K, Rix G
Curr Res Struct Biol
. 2024 Apr;
7:100139.
PMID: 38562944
Phytase enzymes are a crucial component of the natural phosphorus cycle, as they help make phosphate bioavailable by releasing it from phytate, the primary reservoir of organic phosphorus in grain...
2.
Scott B, Chen S, Van Nynatten A, Liu J, Schott R, Heon E, et al.
J Mol Evol
. 2024 Feb;
92(1):61-71.
PMID: 38324225
Eukaryotic cells use G protein-coupled receptors (GPCRs) to convert external stimuli into internal signals to elicit cellular responses. However, how mutations in GPCR-coding genes affect GPCR activation and downstream signaling...
3.
Alperovich N, Scott B, Ross D
PLoS One
. 2023 Oct;
18(10):e0292401.
PMID: 37847718
Although many protocols have been previously developed for genomic DNA (gDNA) extraction from S. cerevisiae, to take advantage of recent advances in laboratory automation and DNA-barcode sequencing, there is a...
4.
Scott B, Lacasse V, Blom D, Tonner P, Blom N
BMC Genom Data
. 2022 Apr;
23(1):25.
PMID: 35379171
Background: The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also...
5.
Scott B, Gutierrez-Vazquez C, Sanmarco L, da Silva Pereira J, Li Z, Plasencia A, et al.
Nat Med
. 2021 Jun;
27(7):1212-1222.
PMID: 34183837
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting...
6.
Scott B, Matochko W, Gierczak R, Bhakta V, Derda R, Sheffield W
PLoS One
. 2020 Sep;
15(9):e0238969.
PMID: 32913368
[This corrects the article DOI: 10.1371/journal.pone.0084491.].
7.
Scott B, Sheffield W
Protein Sci
. 2019 Nov;
29(4):856-871.
PMID: 31774589
α -Antitrypsin (α -AT) serves as an archetypal example for the serine proteinase inhibitor (serpin) protein family and has been used as a scaffold for protein engineering for >35 years....
8.
Scott B, Wybenga-Groot L, McGlade C, Heon E, Peisajovich S, Chang B
SLAS Discov
. 2019 Sep;
24(10):969-977.
PMID: 31556794
Retinitis pigmentosa (RP) is a degenerative retinal disease, often caused by mutations in the G-protein-coupled receptor rhodopsin. The majority of pathogenic rhodopsin mutations cause rhodopsin to misfold, including P23H, disrupting...
9.
Scott B, Chen S, Bhattacharyya N, Moalim A, Plotnikov S, Heon E, et al.
Genetics
. 2018 Dec;
211(2):597-615.
PMID: 30514708
G protein-coupled receptors (GPCRs) are crucial sensors of extracellular signals in eukaryotes, with multiple GPCR mutations linked to human diseases. With the growing number of sequenced human genomes, determining the...
10.
de Souza L, Scott B, Bhakta V, Donkor D, Perruzza D, Sheffield W
Methods Mol Biol
. 2018 Sep;
1826:41-64.
PMID: 30194592
Phage display is a protein engineering approach that involves construction of libraries of variant proteins displayed on the surface of bacteriophage as capsid fusion proteins and their screening for binding...