Benjamin J Strober
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Explore the profile of Benjamin J Strober including associated specialties, affiliations and a list of published articles.
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16
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Recent Articles
1.
Strober B, Zhang M, Amariuta T, Rossen J, Price A
Nat Genet
. 2025 Jan;
57(1):42-52.
PMID: 39747598
Complex diseases often have distinct mechanisms spanning multiple tissues. We propose tissue-gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for each gene-tissue pair to mediate a disease locus...
2.
Rossen J, Shi H, Strober B, Zhang M, Kanai M, McCaw Z, et al.
medRxiv
. 2024 May;
PMID: 38798542
Leveraging data from multiple ancestries can greatly improve fine-mapping power due to differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an extension of the sum of single effects...
3.
Strober B, Tayeb K, Popp J, Qi G, Gordon M, Perez R, et al.
Genome Biol
. 2024 Jan;
25(1):28.
PMID: 38254214
Genetic regulation of gene expression is a complex process, with genetic effects known to vary across cellular contexts such as cell types and environmental conditions. We developed SURGE, a method...
4.
Zhang M, Durvasula A, Chiang C, Koch E, Strober B, Shi H, et al.
Res Sq
. 2024 Jan;
PMID: 38168385
The genetic architecture of human diseases and complex traits has been extensively studied, but little is known about the relationship of causal disease effect sizes between proximal SNPs, which have...
5.
Zhang M, Durvasula A, Chiang C, Koch E, Strober B, Shi H, et al.
medRxiv
. 2023 Dec;
PMID: 38106023
The genetic architecture of human diseases and complex traits has been extensively studied, but little is known about the relationship of causal disease effect sizes between proximal SNPs, which have...
6.
Strober B, Zhang M, Amariuta T, Rossen J, Price A
medRxiv
. 2023 Nov;
PMID: 37961337
Heritable diseases often manifest in a highly tissue-specific manner, with different disease loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine-Mapping (TGFM), a fine-mapping method...
7.
Li T, Ferraro N, Strober B, Aguet F, Kasela S, Arvanitis M, et al.
Cell Genom
. 2023 Oct;
3(10):100401.
PMID: 37868038
Each human genome has tens of thousands of rare genetic variants; however, identifying impactful rare variants remains a major challenge. We demonstrate how use of personal multi-omics can enable identification...
8.
Qi G, Strober B, Popp J, Keener R, Ji H, Battle A
Nat Commun
. 2023 Oct;
14(1):6317.
PMID: 37813843
Differential allele-specific expression (ASE) is a powerful tool to study context-specific cis-regulation of gene expression. Such effects can reflect the interaction between genetic or epigenetic factors and a measured context...
9.
Rhodes K, Barr K, Popp J, Strober B, Battle A, Gilad Y
Elife
. 2022 Feb;
11.
PMID: 35142607
Practically all studies of gene expression in humans to date have been performed in a relatively small number of adult tissues. Gene regulation is highly dynamic and context-dependent. In order...
10.
Arvanitis M, Tayeb K, Strober B, Battle A
Am J Hum Genet
. 2022 Jan;
109(2):223-239.
PMID: 35085493
Uncovering the functional impact of genetic variation on gene expression is important in understanding tissue biology and the pathogenesis of complex traits. Despite large efforts to map expression quantitative trait...