Benjamin J Schmiedel
Overview
Explore the profile of Benjamin J Schmiedel including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
957
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Recent Articles
1.
Upadhye A, Meza Landeros K, Ramirez-Suastegui C, Schmiedel B, Woo E, Chee S, et al.
Nat Cancer
. 2024 Jan;
5(5):791-807.
PMID: 38228835
Brain tumors in children are a devastating disease in a high proportion of patients. Owing to inconsistent results in clinical trials in unstratified patients, the role of immunotherapy remains unclear....
2.
Pagadala M, Sears T, Wu V, Perez-Guijarro E, Kim H, Castro A, et al.
Nat Commun
. 2023 May;
14(1):2744.
PMID: 37173324
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here,...
3.
Schmiedel B, Gonzalez-Colin C, Fajardo V, Rocha J, Madrigal A, Ramirez-Suastegui C, et al.
Sci Immunol
. 2022 Feb;
7(68):eabm2508.
PMID: 35213211
The impact of genetic variants on cells challenged in biologically relevant contexts has not been fully explored. Here, we activated CD4 T cells from 89 healthy donors and performed a...
4.
Schmiedel B, Rocha J, Gonzalez-Colin C, Bhattacharyya S, Madrigal A, Ottensmeier C, et al.
Nat Commun
. 2021 Nov;
12(1):6760.
PMID: 34799557
Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Given the importance of immune cells in the pathogenesis of...
5.
Panwar B, Schmiedel B, Liang S, White B, Rodriguez E, Kalunian K, et al.
Genome Res
. 2021 Mar;
31(4):659-676.
PMID: 33674349
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable heterogeneity in clinical manifestations as well...
6.
Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants
Chandra V, Bhattacharyya S, Schmiedel B, Madrigal A, Gonzalez-Colin C, Fotsing S, et al.
Nat Genet
. 2020 Dec;
53(1):110-119.
PMID: 33349701
Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs...
7.
Schmiedel B, Chandra V, Rocha J, Gonzalez-Colin C, Bhattacharyya S, Madrigal A, et al.
bioRxiv
. 2020 Dec;
PMID: 33299987
Common genetic polymorphisms associated with severity of COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Here, we assessed the effects of 679 COVID-19-risk...
8.
Seumois G, Ramirez-Suastegui C, Schmiedel B, Liang S, Peters B, Sette A, et al.
Sci Immunol
. 2020 Jun;
5(48).
PMID: 32532832
CD4 T helper (T) cells and regulatory T (T) cells that respond to common allergens play an important role in driving and dampening airway inflammation in patients with asthma. Until...
9.
Svensson M, Doody K, Schmiedel B, Bhattacharyya S, Panwar B, Wiede F, et al.
J Clin Invest
. 2019 Jan;
129(3):1193-1210.
PMID: 30620725
Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 inhibits signaling...
10.
Schmiedel B, Singh D, Madrigal A, Valdovino-Gonzalez A, White B, Zapardiel-Gonzalo J, et al.
Cell
. 2018 Nov;
175(6):1701-1715.e16.
PMID: 30449622
While many genetic variants have been associated with risk for human diseases, how these variants affect gene expression in various cell types remains largely unknown. To address this gap, the...