Benjamin J Frisch
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Explore the profile of Benjamin J Frisch including associated specialties, affiliations and a list of published articles.
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25
Citations
660
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Recent Articles
11.
Staversky R, Byun D, Georger M, Zaffuto B, Goodman A, Becker M, et al.
Sci Rep
. 2018 Oct;
8(1):14691.
PMID: 30279500
The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a...
12.
Frisch B
Bone
. 2018 May;
119:8-12.
PMID: 29778716
Hematopoietic stem cells (HSCs) require a supportive microenvironment to regulate their function and produce sufficient hematopoietic cells over the lifetime of an individual. With the exception of fish, all vertebrates,...
13.
Alwaseem H, Frisch B, Fasan R
Bioorg Med Chem
. 2017 Aug;
26(7):1365-1373.
PMID: 28826596
The plant-derived sesquiterpene lactone parthenolide (PTL) was recently found to possess promising anticancer activity but elaboration of this natural product scaffold for optimization of its pharmacological properties has proven challenging...
14.
Lawal R, Zhou X, Batey K, Hoffman C, Georger M, Radtke F, et al.
J Bone Miner Res
. 2017 Mar;
32(6):1320-1331.
PMID: 28277610
Notch signaling is critical for osteoblastic differentiation; however, the specific contribution of individual Notch ligands is unknown. Parathyroid hormone (PTH) regulates the Notch ligand Jagged1 in osteoblastic cells. To determine...
15.
Balderman S, Li A, Hoffman C, Frisch B, Goodman A, LaMere M, et al.
Blood
. 2015 Dec;
127(5):616-25.
PMID: 26637787
In vitro evidence suggests that the bone marrow microenvironment (BMME) is altered in myelodysplastic syndromes (MDSs). Here, we study the BMME in MDS in vivo using a transgenic murine model...
16.
17.
Frisch B, Calvi L
Methods Mol Biol
. 2014 Feb;
1130:315-324.
PMID: 24482184
The adult hematopoietic system is repopulated in its entirety from a rare cell type known as hematopoietic stem cells (HSCs) that reside in the marrow space throughout the skeletal system....
18.
Porter R, Georger M, Bromberg O, McGrath K, Frisch B, Becker M, et al.
Stem Cells
. 2012 Nov;
31(2):372-83.
PMID: 23169593
Hematopoietic stem and progenitor cells (HSPCs), which continuously maintain all mature blood cells, are regulated within the marrow microenvironment. We previously reported that pharmacologic treatment of naïve mice with prostaglandin...
19.
Loiselle A, Frisch B, Wolenski M, Jacobson J, Calvi L, Schwarz E, et al.
PLoS One
. 2012 Jul;
7(7):e40602.
PMID: 22792383
The pathogenesis of adhesions following primary tendon repair is poorly understood, but is thought to involve dysregulation of matrix metalloproteinases (Mmps). We have previously demonstrated that Mmp9 gene expression is...
20.
Bromberg O, Frisch B, Weber J, Porter R, Civitelli R, Calvi L
Blood
. 2012 May;
120(2):303-13.
PMID: 22596259
Hematopoietic stem cell (HSC) regulation is highly dependent on interactions with the marrow microenvironment. Controversy exists on N-cadherin's role in support of HSCs. Specifically, it is unknown whether microenvironmental N-cadherin...