Benjamin J Frisch
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Explore the profile of Benjamin J Frisch including associated specialties, affiliations and a list of published articles.
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25
Citations
660
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Recent Articles
1.
Soto C, Lesch M, Becker J, Sharipol A, Khan A, Schafer X, et al.
bioRxiv
. 2024 Aug;
PMID: 39185193
Interactions between acute myeloid leukemia (AML) and the bone marrow microenvironment (BMME) are critical to leukemia progression and chemoresistance. In the solid tumor microenvironment, altered metabolite levels contribute to cancer...
2.
Kawano Y, Kawano H, Ghoneim D, Fountaine T, Byun D, LaMere M, et al.
bioRxiv
. 2023 Apr;
PMID: 37066307
Mesenchymal stem/stromal cells (MSCs) within the bone marrow microenvironment (BMME) support normal hematopoietic stem and progenitor cells (HSPCs). However, the heterogeneity of human MSCs has limited the understanding of their...
3.
Sharipol A, Lesch M, Soto C, Frisch B
Front Bioeng Biotechnol
. 2022 Jul;
10:855777.
PMID: 35795163
Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow...
4.
Ackun-Farmmer M, Alwaseem H, Counts M, Bortz A, Giovani S, Frisch B, et al.
Adv Ther (Weinh)
. 2022 Jan;
5(1).
PMID: 35097186
Micheliolide (MCL) is a naturally occurring sesquiterpene lactone that selectively targets leukemic stem cells (LSCs), which persist after conventional chemotherapy for myeloid leukemias, leading to disease relapse. To overcome modest...
5.
Soto C, Lo Celso C, Purton L, Frisch B
JBMR Plus
. 2021 Oct;
5(10):e10516.
PMID: 34693187
The bone marrow microenvironment (BMME) regulates hematopoiesis through a complex network of cellular and molecular components. Hematologic malignancies reside within, and extensively interact with, the same BMME. These interactions consequently...
6.
Ackun-Farmmer M, Soto C, Lesch M, Byun D, Yang L, Calvi L, et al.
FASEB J
. 2021 Mar;
35(4):e21402.
PMID: 33724567
Leukemias are challenging diseases to treat due, in part, to interactions between leukemia cells and the bone marrow microenvironment (BMME) that contribute significantly to disease progression. Studies have shown that...
7.
Frisch B
Methods Mol Biol
. 2020 Nov;
2230:467-477.
PMID: 33197034
The adult hematopoietic system is repopulated in its entirety from a rare cell type known as hematopoietic stem cells (HSCs) that reside in the marrow space throughout the skeletal system....
8.
Calvi L, Frisch B, Kingsley P, Koniski A, Love T, Williams J, et al.
Int J Radiat Biol
. 2019 Jul;
95(11):1447-1461.
PMID: 31329495
Incidents, such as nuclear facility accidents and the release of a 'dirty bomb', might result in not only external irradiation of personnel, but additional internal exposures through concomitant inhalation and/or...
9.
Frisch B, Hoffman C, Latchney S, LaMere M, Myers J, Ashton J, et al.
JCI Insight
. 2019 Apr;
5.
PMID: 30998506
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction...
10.
Ayoub E, Wilson M, McGrath K, Li A, Frisch B, Palis J, et al.
Nat Commun
. 2018 Oct;
9(1):4239.
PMID: 30315161
Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which...