Benjamin J Capoccia
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Explore the profile of Benjamin J Capoccia including associated specialties, affiliations and a list of published articles.
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14
Citations
613
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Recent Articles
1.
Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells
Andrejeva G, Capoccia B, Hiebsch R, Donio M, Darwech I, Puro R, et al.
J Immunol
. 2021 Jan;
206(4):712-721.
PMID: 33431660
The signal regulatory protein α (SIRPα)/CD47 axis has emerged as an important innate immune checkpoint that enables cancer cell escape from macrophage phagocytosis. SIRPα expression is limited to macrophages, dendritic...
2.
Puro R, Bouchlaka M, Hiebsch R, Capoccia B, Donio M, Manning P, et al.
Mol Cancer Ther
. 2019 Dec;
19(3):835-846.
PMID: 31879362
Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal tissues and overexpressed on many tumors. Binding of...
3.
Xiao Z, Chung H, Banan B, Manning P, Ott K, Lin S, et al.
Cancer Lett
. 2015 Feb;
360(2):302-9.
PMID: 25721088
Human hepatocellular carcinoma (HCC) has a high rate of tumor recurrence and metastasis, resulting in shortened survival times. The efficacy of current systemic therapies for HCC is limited. In this...
4.
Lin Y, Manning P, Jia J, Gaut J, Xiao Z, Capoccia B, et al.
Transplantation
. 2014 Jul;
98(4):394-401.
PMID: 24983310
Background: Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling....
5.
Capoccia B, Jin R, Kong Y, Peek Jr R, Fassan M, Rugge M, et al.
J Clin Invest
. 2013 Mar;
123(4):1475-91.
PMID: 23478405
After cell fate specification, differentiating cells must amplify the specific subcellular features required for their specialized function. How cells regulate such subcellular scaling is a fundamental unanswered question. Here, we...
6.
Nguyen T, Khurana S, Bellone C, Capoccia B, Sagartz J, Kesman Jr R, et al.
Cancer Res
. 2013 Feb;
73(7):2117-26.
PMID: 23378345
Chronic inflammation is a major risk factor for cancer, including gastric cancers and other gastrointestinal cancers. For example, chronic inflammation caused by autoimmune gastritis (AIG) is associated with an increased...
7.
Capoccia B, Lennerz J, Bredemeyer A, Klco J, Frater J, Mills J
Physiol Genomics
. 2010 Nov;
43(3):174-86.
PMID: 21098683
Despite their divergent developmental ancestry, plasma cells and gastric zymogenic (chief) cells share a common function: high-capacity secretion of protein. Here we show that both cell lineages share increased expression...
8.
Gregory A, Capoccia B, Woloszynek J, Link D
J Leukoc Biol
. 2010 Apr;
88(1):123-31.
PMID: 20354107
There is considerable interest in the potential of cell-based approaches to mediate therapeutic angiogenesis for acute and chronic vascular syndromes. Using a mouse model of HLI, we showed previously that...
9.
Capoccia B, Robson D, Levac K, Maxwell D, Hohm S, Neelamkavil M, et al.
Blood
. 2009 Mar;
113(21):5340-51.
PMID: 19324906
The development of cell therapies to treat peripheral vascular disease has proven difficult because of the contribution of multiple cell types that coordinate revascularization. We characterized the vascular regenerative potential...
10.
Capoccia B, Huh W, Mills J
Physiol Genomics
. 2009 Feb;
37(2):67-78.
PMID: 19208773
The cellular composition and morphology of the stomach epithelium have been described in detail; however, the molecular mechanisms that regulate the differentiation of the various cell lineages as well as...