Benjamin G Tehan
Overview
Explore the profile of Benjamin G Tehan including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
357
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Recent Articles
1.
Palacios-Filardo J, Udakis M, Brown G, Tehan B, Congreve M, Nathan P, et al.
Nat Commun
. 2021 Dec;
12(1):7265.
PMID: 34880229
No abstract available.
2.
Brown A, Bradley S, Marshall F, Brown G, Bennett K, Brown J, et al.
Cell
. 2021 Nov;
184(24):5886-5901.e22.
PMID: 34822784
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative...
3.
Palacios-Filardo J, Udakis M, Brown G, Tehan B, Congreve M, Nathan P, et al.
Nat Commun
. 2021 Sep;
12(1):5475.
PMID: 34531380
Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to enhance...
4.
Stott L, Brighton C, Brown J, Mould R, Bennett K, Newman R, et al.
Heliyon
. 2021 Jun;
7(6):e07201.
PMID: 34189291
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction...
5.
Bennett K, Christopher J, Tehan B
Adv Pharmacol
. 2020 May;
88:35-58.
PMID: 32416871
The metabotropic glutamate (mGlu) receptors are a family of eight class C G protein-coupled receptors (GPCRs) which modulate cell signaling and synaptic transmission to the major excitatory neurotransmitter l-glutamate (l-glutamic...
6.
Rappas M, Ali A, Bennett K, Brown J, Bucknell S, Congreve M, et al.
J Med Chem
. 2019 Dec;
63(4):1528-1543.
PMID: 31860301
The orexin system, which consists of the two G protein-coupled receptors OX and OX, activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral...
7.
Bortolato A, Tehan B, Smith R, Mason J
Methods Mol Biol
. 2017 Dec;
1705:207-232.
PMID: 29188565
The following chapter examines some of the current "state-of-the-art" tools for predicting, scoring, and examining explicit water molecules in proteins and protein/ligand complexes, highlighting some of the ways information can...
8.
Christopher J, Dore A, Tehan B
Curr Top Med Chem
. 2016 Jul;
17(1):71-78.
PMID: 27448651
Class C G protein-coupled receptors encompass a range of promising therapeutic targets for a variety of diseases, yet to date only two members of this sub-family of GPCRs have been...
9.
Tehan B, Christopher J
Curr Opin Pharmacol
. 2016 Jul;
30:8-13.
PMID: 27400445
Recent developments in receptor stabilisation have facilitated major advances in G protein-coupled receptor (GPCR) research, notably structural biology, over the past eight years. Here we review the application of fragment,...
10.
Harpsoe K, Isberg V, Tehan B, Weiss D, Arsova A, Marshall F, et al.
Sci Rep
. 2015 Sep;
5:13869.
PMID: 26359761
The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological...